Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future

被引：10
|
作者：
Bienz, Marc [1 ,2 ]
Ramdani, Salima [2 ]
Knecht, Hans [1 ,2 ]
机构：
[1] McGill Univ, Jewish Gen Hosp, Dept Med, Div Hematol, Montreal, PQ H3T 1E2, Canada
[2] McGill Univ, Dept Med, Montreal, PQ H3T 1E2, Canada
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 18期
关键词：
classical Hodgkin lymphoma; Hodgkin cells; Reed-Sternberg cells; genetic instability; telomere dysfunction; shelterin; TRF2; Lamin A; C; REED-STERNBERG CELLS; EPSTEIN-BARR-VIRUS; NF-KAPPA-B; IMMUNOGLOBULIN GENE REARRANGEMENTS; TELOMERE TERMINAL TRANSFERASE; NUCLEAR ARCHITECTURE; CHROMOSOMAL REARRANGEMENTS; T-CELLS; DISEASE; EXPRESSION;
D O I：
10.3390/ijms21186623
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Our understanding of the tumorigenesis of classical Hodgkin lymphoma (cHL) and the formation of Reed-Sternberg cells (RS-cells) has evolved drastically in the last decades. More recently, a better characterization of the signaling pathways and the cellular interactions at play have paved the way for new targeted therapy in the hopes of improving outcomes. However, important gaps in knowledge remain that may hold the key for significant changes of paradigm in this lymphoma. Here, we discuss the past, present, and future of cHL, and review in detail the more recent discoveries pertaining to genetic instability, anti-apoptotic signaling pathways, the tumoral microenvironment, and host-immune system evasion in cHL.
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页码：1 / 16
页数：16
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