The Notch and Sonic hedgehog signalling pathways in immunity

被引：31
|
作者：
Benson, RA [1 ]
Lowrey, JA [1 ]
Lamb, JR [1 ]
Howie, SEM [1 ]
机构：
[1] Univ Edinburgh, Immunobiol Grp, MRC, Ctr Inflammat Res,Coll Med & Vet Med, Edinburgh EH8 9AG, Midlothian, Scotland
来源：
MOLECULAR IMMUNOLOGY | 2004年 / 41卷 / 6-7期
关键词：
Notch; Sonic hedgehog; CD4+ T cells; cytokines; thymocytes;
D O I：
10.1016/j.molimm.2004.04.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
There is an increasing body of knowledge demonstrating that genes involved in cell fate decisions during development also play a role in the continuous cell fate decisions made by the mature immune system in response to foreign antigen. This review concentrates on the role of the Notch and Sonic hedgehog (Shh) signalling pathways in the development and function of CD4(+) T lymphocytes. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：715 / 725
页数：11
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