Synthesis and Anti-hepatitis B Virus Activities of Nitric Oxide-Releasing Derivatives of Matijin-Su

被引：6

作者：

Liang, Guangping ^{[1
,2
,3
]}

Cao, Peixue ^{[1
,2
]}

Yang, Xiuxie ^{[1
,2
,3
]}

Huang, Zhengming ^{[4
]}

Liu, Qingchuan ^{[4
]}

Liang, Guangyi ^{[1
,2
,3
]}

Xu, Bixue ^{[1
,2
,3
]}

机构：

[1] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China

[2] Chinese Acad Sci, Guiyang 550002, Peoples R China

[3] Guiyang Coll Tradit Chinese Med, Guiyang 550002, Peoples R China

[4] 302 Hosp PLA, Beijing 100039, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 34卷 / 05期

基金：

中国国家自然科学基金;

关键词：

derivatives of Matijin-Su; nitric oxide donor; synthesis; anti-hepatitis B virus activity;

D O I：

10.6023/cjoc201312003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By using N-(N-benzoyl-L-phenylalanyl)-O-acetyl-L-phenylalanol, named Matijin-Su, as a lead compound, a series of nitric oxide-releasing derivatives of Matijin-Su were synthesized and evaluated for their anti-hepatitis B virus activities in HepG2 2.2.15 cells. Compounds 6d, 6e and 6g exhibited significant anti-HBV activities. The 50% inhibitory concentrations of these compounds towards HepG2 2.2.15 cells were 6.88, 37.51 and 11.07 mu mol/L. Compounds 6d and 6g were less than Matijin-Su (IC50: 11.16 mu mol/L). Compound 6d has potent in vitro anti-HBV activity, and could be worth of further research.

引用

页码：973 / 979

页数：7

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