Allosteric p38 kinase inhibitors

被引：2

作者：

Norman, Peter ^{[1
]}

机构：

[1] Norman Consulting, Burnham SL1 8JW, Bucks, England

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2006年 / 16卷 / 10期

关键词：

IL-1; MAPK; p38; rheumatoid arthritis; TNF-alpha;

D O I：

10.1517/13543776.16.10.1443

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two applications claim N,N'-bisaryl urea derivatives as allosteric inhibitors of p38 MAPK and their use as anti-inflammatory agents. The compounds have been designed to stabilise a specific conformation of the kinase and to optimise selectivity by avoiding interactions with the ATP-binding domain of the kinase. They are the first application to describe the applicant's p38 inhibitor programme, which is close to investigational new drug filing.

引用

页码：1443 / 1448

页数：6

共 50 条

[1] Allosteric and slow binding inhibitors of p38 MAP kinase.
Regan, J
Breitfelder, S
Cirillo, P
Gilmore, T
Graham, A
Hickey, E
Madwed, J
Moriak, M
Moss, N
Pargellis, C
Proto, A
Tong, L
Torcellini, C
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 222 : U683 - U683
[2] P38 kinase inhibitors
Lloyd, AW
[J]. DRUG DISCOVERY TODAY, 2000, 5 (12) : 570 - 571
[3] Inhibitors of p38 kinase
Hanson, GJ
[J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 1997, 7 (07) : 729 - 733
[4] Inhibitors of p38α MAP kinase
Chakravarty, S
[J]. ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 37, 2002, 37 : 177 - 186
[5] New inhibitors of p38 kinase
Boehm, JC
Adams, JL
[J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 2000, 10 (01) : 25 - 37
[6] Substituted pyrazoles as p38 kinase inhibitors
[J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 1999, 9 (07) : 975 - 979
[7] The development p38 MAP kinase inhibitors
Hynes, John
Wu, H.
Dyckman, A. J.
Lin, S.
Wrobleski, S. T.
Gillooly, K. M.
McIntyre, K. W.
Pitt, S.
Shen, D. R.
Shuster, D. J.
Xia, X.
Zhang, R.
[J]. INFLAMMATION RESEARCH, 2007, 56 : S474 - S474
[8] Potent inhibitors of the map kinase p38
Henry, JR
Rupert, KC
Dodd, JH
Turchi, IJ
Wadsworth, SA
Cavender, DE
Schafer, PH
Siekierka, JJ
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (23) : 3335 - 3340
[9] Aminopyrimidinylimidazoles as inhibitors of P38 kinase (CSBP).
Gallagher, TF
Boehm, JC
Osifo, IK
Kassis, S
Lee, JC
Griswold, DE
Ayrton, A
Adams, JL
Wang, Z
Goldsmith, EJ
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 215 : U894 - U894
[10] Inhibitors of unactivated p38 MAP kinase
Bullington, James
Argentieri, Dennis
Averill, Kristin
Carter, Demetrius
Cavender, Druie
Fahmy, Bohumila
Fan, Xiaodong
Hall, Daniel
Heintzelman, Geoffrey
Jackson, Paul
Leung, Wai-Ping
Li, Xun
Ling, Ping
Olini, Gilbert
Razler, Thomas
Reuman, Michael
Rupert, Kenneth
Russell, Ronald
Siekierka, John
Wadsworth, Scott
Wolff, Russell
Xiang, Bangping
Zhang, Yue-Mei
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (23) : 6102 - 6106

← 1 2 3 4 5 →