BODIPY-Based Fluorescent Probe for Peroxynitrite Detection and Imaging in Living Cells

被引：156
|
作者：
Sun, Zhen-Ning [1 ]
Wang, Hua-Li [1 ]
Liu, Feng-Qin [2 ]
Chen, Yan [2 ]
Tam, Paul Kwong Hang [1 ]
Yang, Dan [1 ]
机构：
[1] Univ Hong Kong, Morningside Lab Chem Biol, Dept Chem, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 09期
关键词：
NITRIC-OXIDE; REACTIVE OXYGEN; CHEMISTRY; DESIGN; DYES;
D O I：
10.1021/ol900279z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A fluorescent probe, HKGreen-2, has been developed based on a specific reaction between ketone and peroxynitrite (ONOO-). This probe is highly sensitive and selective for the detection of peroxynitrite not only in abiotic but also in biological systems. With this probe, we successfully detected peroxynitrite generated in murine macrophage cells activated by phorbol 12-myristate 13-acetate (PMA), interferon-gamma (IFN-gamma), and lipopolysaccharide (LPS). This new probe will be a useful tool for studying the roles of peroxynitrite in biological processes.
引用
收藏
页码：1887 / 1890
页数：4
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