RP-HPLC method for the simultaneous determination of valdecoxib and paracetamol in tablet dosage form

被引：0
|
作者：
Rajeswari, K. Raja [1 ]
Sankar, G. G. [1 ]
Rao, A. L. [1 ]
Raju, D. B. [1 ]
Rao, J. V. L. N. Seshagiri [1 ]
机构：
[1] Shri Vishnu Coll Pharm, Dept Pharmaceut Sci, Vishnupur 534202, Bhimavaram, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2006年 / 18卷 / 04期
关键词：
RP-BPLC; valdecoxib; paracetamol;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple, precise, accurate and rapid RP-HPLC method has been developed and validated for the simultaneous determination of valdecoxib and paracetamol in combined tablet dosage form. The mobile phase used was a mixture of methanol and water (55 : 45) (v/v). The detection of valdecoxib and paracetamol was carried out on dual lambda(max) absorbance detector at 243 and 245 nm, respectively. Results of the analysis Were validated statistically and by recovery studies. The proposed method can be successfully used to determine the drug contents of marketed formulation.
引用
收藏
页码：3117 / 3119
页数：3
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