Effect of the product type, of the amount of applied sunscreen product and the level of protection in the UVB range on the level of protection achieved in the UVA range

被引:13
|
作者
Couteau, C. [1 ]
Diarra, H. [2 ,3 ]
Coiffard, L. [1 ]
机构
[1] Nantes Atlant Univ, Univ Nantes, LPiC, Fac Pharm,MMS,EA2160, 9 Rue Bias, F-44000 Nantes, France
[2] Univ Bordeaux, CNRS, Inst Mech Engn, Pharmaceut & Biopharma Lab,UMR 5295, I2 M,Batiment Pharm 1ere Tranche,3eme Etage, F-33076 Bordeaux, France
[3] Univ Paris 11, 5 Rue Jean Baptiste Clement, F-92296 Chatenay Malabry, France
关键词
Sunscreens; Oil; Creams; Protection factor UVA (PF-UVA); Amount of product; SPF;
D O I
10.1016/j.ijpharm.2016.01.041
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Using a topical product is part of the overall strategy for skin cancer prevention. The level of protection attainable when using commercial products is indicated by the Sun Protection Factor (SPF) value, in use everywhere. This value reflects the level of protection primarily in the UVB range. However, UVA radiation also has deleterious effects on the skin, and it is essential to prevent it, which is why products must offer a wide spectrum of protection. Tests conducted in vivo, before any marketing, are done by applying the studied product at a rate of 2.0 mg cm(-2), while users, in practice, only use 1.0-1.5 mg cm(-2). We now know that this reduction in the amount of applied product greatly affects the SPF. To complete the state of knowledge in this area, we sought to evaluate the effect of a decrease in the amount of applied sunscreen product by studying sunscreen creams and oils on the level of protection attainable in the UVA range. We have shown that the PF-UVA is divided by a factor of 2.2, on average, when the amount of applied product is reduced by half, with differences depending on the product type under consideration (cream or oil) and depending on the SPF of the preparation. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:210 / 216
页数:7
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