Purinergic Regulation of Endothelial Barrier Function

被引：22

作者：

Aslam, Muhammad ^{[1
,2
,3
]}

Gunduz, Dursun ^{[1
,4
]}

Troidl, Christian ^{[1
,2
,3
]}

Heger, Jacqueline ^{[5
]}

Hamm, Christian W. ^{[1
,2
,3
]}

Schulz, Rainer ^{[5
]}

机构：

[1] Justus Liebig Univ, Dept Internal Med 1, Expt Cardiol, Aulweg 129, D-35392 Giessen, Germany

[2] Kerckhoff Clin GmbH, Dept Cardiol, D-61231 Bad Nauheim, Germany

[3] DZHK German Ctr Cardiovasc Res, Partner Site Rhein Main, D-61231 Bad Nauheim, Germany

[4] Evangel Jung Stilling Krankenhaus GmbH, Dept Cardiol & Angiol, D-57074 Siegen, Germany

[5] Justus Liebig Univ, Inst Physiol, D-35392 Giessen, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 03期

关键词：

Rac1; RhoA; peripheral actin; adenosine; ATP; ADP; UTP; endothelial permeability; oedema; P2X receptors; P2Y receptors;

D O I：

10.3390/ijms22031207

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Increased vascular permeability is a hallmark of several cardiovascular anomalies, including ischaemia/reperfusion injury and inflammation. During both ischaemia/reperfusion and inflammation, massive amounts of various nucleotides, particularly adenosine 5 '-triphosphate (ATP) and adenosine, are released that can induce a plethora of signalling pathways via activation of several purinergic receptors and may affect endothelial barrier properties. The nature of the effects on endothelial barrier function may depend on the prevalence and type of purinergic receptors activated in a particular tissue. In this review, we discuss the influence of the activation of various purinergic receptors and downstream signalling pathways on vascular permeability during pathological conditions.

引用

页码：1 / 18

页数：18

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