Modulating the Microbiome and Immune Responses Using Whole Plant Fibre in Synbiotic Combination with Fibre-Digesting Probiotic Attenuates Chronic Colonic Inflammation in Spontaneous Colitic Mice Model of IBD

被引：19

作者：

Shinde, Tanvi ^{[1
,2
]}

Vemuri, Ravichandra ^{[2
,3
]}

Shastri, Sonia ^{[2
]}

Perera, Agampodi Promoda ^{[2
]}

Gondalia, Shakuntla, V ^{[4
,5
]}

Beale, David J. ^{[6
]}

Karpe, Avinash, V ^{[6
]}

Eri, Rajaraman ^{[2
]}

Stanley, Roger ^{[1
]}

机构：

[1] Univ Tasmania, Ctr Food Innovat, Tasmanian Inst Agr, Launceston, Tas 7250, Australia

[2] Univ Tasmania, Coll Hlth & Med, Sch Hlth Sci, Gut Hlth Res Grp, Launceston, Tas 7250, Australia

[3] Wake Forest Sch Med, Dept Pathol, Med Ctr Blvd, Winston Salem, NC 27157 USA

[4] Swinburne Univ Technol, Ctr Human Psychopharmacol, Hawthorn, Vic 3122, Australia

[5] Commonwealth Sci & Ind Res Org CSIRO, Hlth & Biosecur, Gate 13 Kintore Ave, Adelaide, SA 5000, Australia

[6] Commonwealth Sci & Ind Res Org CSIRO, Land & Water, Dutton Pk, Qld 4102, Australia

来源：

NUTRIENTS | 2020年 / 12卷 / 08期

关键词：

synbiotic; prebiotic; probiotic; Inflammatory Bowel Diseases (IBD); Bacillusspores; whole plant sugarcane fibre; Short chain fatty acids (SCFAs); dysbiosis; gut microbiota; AKKERMANSIA-MUCINIPHILA; GUT MICROBIOTA; MOUSE MODEL; DIETARY POLYPHENOLS; BOWEL-DISEASE; MUCIN; BACTERIA; MUCOSAL; FERMENTATION; INTEGRITY;

D O I：

10.3390/nu12082380

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

A probiotic and prebiotic food ingredient combination was tested for synergistic functioning in modulation of the colonic microbiome and remediation of the gastrointestinal immune and inflammatory responses in a spontaneous colitic mouse model.Bacillus coagulansMTCC5856 spores with capability to metabolise complex plant polysaccharides were supplemented with complex whole-plant prebiotic sugarcane fibre (PSCF). The combined and individual efficacies were tested for their influence on the outcomes of chronic inflammation inMuc2mutant colitic Winnie mice. The mice were fed normal chow diet supplemented with either ingredient or a combination for 21 days. Synbiotic combined supplementation ameliorated clinical symptoms and histological colonic damage scores more effectively than eitherB. coagulansor PSCF alone. PSCF andB. coagulansalone also induced considerable immunomodulatory effects. Synbiotic supplementation however was the most efficacious in modulating the overall immune profile compared to the unsupplemented Winnie-control. The augmented synbiotic effect could potentially be due to a combination of increased levels of fermentation products, direct immune-modulating abilities of the components, their capability to reduce colonic epithelial damage and/or modulation of the microbiota. The beneficial effects of the supplementation with a complex plant fibre and a fibre-degrading probiotic parallel the effects seen in human microbiota with high plant fibre diets.

引用

页码：1 / 26

页数：26