Determination of ornidazole in pharmaceutical dosage forms based on reduction at an activated glassy carbon electrode

The electrochemical reduction of ornidazole was studied at a glassy carbon electrode activated by applying a new pretreatment. The dependence of intensities of currents and potentials on pH, concentration, scan rate, nature of the solvent (aqueous media, mixed aqueous-organic systems) and surfactant was investigated. Linear calibration plots were obtained over the concentration ranges 4 x 10(-6)-6 x 10(-4) and 6 x 10(-6)-6 x 10-4 mol l(-1) in 0.2 M H2SO4 and acetate buffer (pH 4.7), respectively. The method was applied to the determination of ornidazole in different drug formulations. (C) 1997 Elsevier Science B.V.