Benzoquinones inhibit the expression of inducible nitric oxide synthase gene

被引：16
|
作者：
Niwa, M
Nakamura, N
Kitajima, K
Ueda, M
Tsutsumishita, Y
Futaki, S
Takaishi, Y
机构：
[1] Faculty of Pharmaceutical Sciences, University of Tokushima, Tokushima
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 239卷 / 02期
关键词：
D O I：
10.1006/bbrc.1997.7437
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Benzoquinones inhibited the production of NO induced by LPS and gamma-IFN in C6 glia cells, The mechanistic studies showed that benzoquinones inhibited the expression of iNOS mRNA through inactivation of NF kappa B. Benzoquinones may be a useful candidate for the development of a drug to treat disease due to iNOS gene over-expression. (C) 1997 Academic Press.
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页码：367 / 371
页数：5
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