Strong stability of optimal design to dynamic system for the fed-batch culture

Most economic and industrial processes are governed by inherently nonlinear dynamic system in which mathematical analysis (with few exceptions) is unable to provide general solutions; even the conditions to the existence of equilibrium point for the nonlinear dynamic system are simply not established in some special cases. In this paper, based on numerical solution of a nonlinear multi-stage automatic control dynamic (NMACD) in fed-batch culture of glycerol bioconversion to 1,3-propanediol (1,3-PD) induced by Klebsiella pneumoniae (K. pneumoniae), we consider an optimal design of the NMACD system. For convenience, the NMACD system is reconstructed together with the existence, uniqueness and continuity of solutions are discussed. Our goal is to prove the strong stability with respect to the perturbation of initial state for the solution to the NMACD system. To this end, we construct corresponding linear variational system for the solution to the NMACD system, and also prove the boundedness of fundamental matrix solutions to the linear variational system. On this basis, we prove the strong stability appearing above through the application of this boundedness.