Gold-Catalyzed Oxidative Cross-Coupling of Terminal Alkynes: Selective Synthesis of Unsymmetrical 1,3-Diynes

被引：160
|
作者：
Peng, Haihui [1 ]
Xi, Yumeng [1 ]
Ronaghi, Nima [1 ]
Dong, Boliang [1 ]
Akhmedov, Novruz G. [1 ]
Shi, Xiaodong [1 ]
机构：
[1] W Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 38期
基金：
美国国家科学基金会;
关键词：
COPE-TYPE HYDROAMINATION; POLYSUBSTITUTED FURANS; REDUCTIVE ELIMINATION; H FUNCTIONALIZATION; EFFICIENT SYNTHESIS; CONJUGATED DIYNES; COMPLEXES; ALKYNYLATION; REACTIVITY; OXIDANT;
D O I：
10.1021/ja5078365
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Gold-catalyzed oxidative cross-coupling of allcynes to unsymmetrical diynes has been achieved for the first time. A N,N-ligand (1,10-Phen) and PhI(OAc())2 were identified as crucial factors to promote this transformation, giving the desired cross-coupled conjugated diynes in excellent heteroselectivity (>10:1), in good to excellent yields, and with large substrate tolerability.
引用
收藏
页码：13174 / 13177
页数：4
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