Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns Findings From the Pregnancy and Childhood Epigenetics Consortium

被引：77

作者：

Kazmi, Nabila ^{[1
,2
]}

Sharp, Gemma C. ^{[1
,2
,3
]}

Reese, Sarah E. ^{[4
]}

Vehmeijer, Florianne O. ^{[5
,6
,7
]}

Lahti, Jari ^{[8
,9
]}

Page, Christian M. ^{[11
,13
]}

Zhang, Weiming ^{[14
]}

Rifas-Shiman, Sheryl L. ^{[18
]}

Rezwan, Faisal I. ^{[19
]}

Simpkin, Andrew J. ^{[1
,21
]}

Burrows, Kimberley ^{[1
,2
]}

Richardson, Tom G. ^{[1
,2
]}

Ferreira, Diana L. Santos ^{[1
,2
]}

Fraser, Abigail ^{[1
,2
]}

Harmon, Quaker E. ^{[4
]}

Zhao, Shanshan ^{[4
]}

Jaddoe, Vincent W. V. ^{[5
,6
,7
]}

Czamara, Darina ^{[22
]}

Binder, Elisabeth B. ^{[22
,23
]}

Magnus, Maria C. ^{[1
,2
,12
]}

Haberg, Siri E. ^{[12
]}

Nystad, Wenche ^{[11
]}

Nohr, Ellen A. ^{[24
]}

Starling, Anne P. ^{[15
]}

Kechris, Katerina J. ^{[14
]}

Yang, Ivana V. ^{[15
,16
,25
]}

DeMeo, Dawn L. ^{[26
]}

Litonjua, Augusto A. ^{[27
]}

Baccarelli, Andrea ^{[28
]}

Oken, Emily ^{[18
]}

Holloway, John W. ^{[19
,20
]}

Karmaus, Wilfried ^{[29
]}

Arshad, Syed H. ^{[20
]}

Dabelea, Dana ^{[15
,17
]}

Sorensen, Thorkild I. A. ^{[1
,30
,31
]}

Laivuori, Hannele ^{[10
,32
,33
,34
,35
,36
]}

Raikkonen, Katri ^{[8
]}

Felix, Janine F. ^{[5
,6
,7
]}

London, Stephanie J. ^{[4
]}

Hivert, Marie-France ^{[18
,37
]}

Gaunt, Tom R. ^{[1
,2
,38
]}

Lawlor, Debbie A. ^{[1
,2
,38
]}

Relton, Caroline L. ^{[1
,2
,38
]}

机构：

[1] Univ Bristol, MRC Integrat Epidemiol Unit, Oakfield House, Bristol BS8 2BN, Avon, England

[2] Univ Bristol, Populat Hlth Sci, Bristol Med Sch, Bristol, Avon, England

[3] Univ Bristol, Sch Oral & Dent Sci, Bristol, Avon, England

[4] NIEHS, Div Intramural Res, Dept Hlth & Human Serv, NIH, Durham, NC USA

[5] Univ Med Ctr, Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands

[6] Univ Med Ctr, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[7] Univ Med Ctr, Erasmus MC, Dept Pediat, Rotterdam, Netherlands

[8] Univ Helsinki, Dept Psychol & Logoped, Fac Med, Helsinki, Finland

[9] Univ Helsinki, Helsinki Coll Adv Studies, Helsinki, Finland

[10] Univ Helsinki, Inst Mol Med Finland, Helsinki Inst Life Sci, Helsinki, Finland

[11] Norwegian Inst Publ Hlth, Div Mental & Phys Hlth, Oslo, Norway

[12] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, Oslo, Norway

[13] Oslo Univ Hosp, Oslo Ctr Biostat & Epidemiol, Oslo, Norway

[14] Univ Colorado, Dept Biostat & Informat, Anschutz Med Campus, Aurora, CO USA

[15] Univ Colorado, Dept Epidemiol, Anschutz Med Campus, Aurora, CO USA

[16] Univ Colorado, Dept Med, Anschutz Med Campus, Aurora, CO USA

[17] Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO USA

[18] Harvard Med Sch, Harvard Pilgrim Hlth Care Inst, Dept Populat Med, Boston, MA 02115 USA

[19] Univ Southampton, Fac Med, Human Dev & Hlth, Southampton, Hants, England

[20] Univ Southampton, Fac Med, Clin & Expt Sci, Southampton, Hants, England

[21] Natl Univ Ireland, Insight Ctr Data Analyt, Galway, Ireland

[22] Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany

[23] Emory Univ, Dept Psychiat & Behav Sci, Sch Med, Atlanta, GA 30322 USA

[24] Univ Southern Denmark, Dept Clin Res, Res Unit Gynaecol & Obstet, Odense, Denmark

[25] Natl Jewish Hlth, Ctr Genes Environm & Hlth, Denver, CO USA

[26] Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA

[27] Univ Rochester, Div Pediat Pulm Med, Med Ctr, Rochester, NY 14627 USA

[28] Columbia Univ, Lab Precis Environm Biosci, Mailman Sch Publ Hlth, New York, NY USA

[29] Univ Memphis, Sch Publ Hlth, Div Epidemiol Biostat & Environm Hlth, Memphis, TN 38152 USA

[30] Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Genet, Copenhagen, Denmark

[31] Univ Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, Epidemiol Sect, Copenhagen, Denmark

[32] Univ Helsinki, Med & Clin Genet, Helsinki, Finland

[33] Helsinki Univ Hosp, Helsinki, Finland

[34] Univ Tampere, Fac Med & Life Sci, Tampere, Finland

[35] Tampere Univ Hosp, Dept Obstet & Gynecol, Tampere, Finland

[36] Univ Helsinki, Helsinki Inst Life Sci, Inst Mol Med, Helsinki, Finland

[37] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA

[38] NIHR Bristol Biomed Res Ctr, Bristol, Avon, England

来源：

HYPERTENSION | 2019年 / 74卷 / 02期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

cardiovascular diseases; DNA methylation; gestational age; hypertension; preeclampsia; BLOOD-PRESSURE; FETAL-GROWTH; NORWEGIAN MOTHER; GENERATION R; COHORT; BIRTH; ASSOCIATIONS; HYPOMETHYLATION; METAANALYSIS; VASOPRESSIN;

D O I：

10.1161/HYPERTENSIONAHA.119.12634

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Hypertensive disorders of pregnancy (HDP) are associated with low birth weight, shorter gestational age, and increased risk of maternal and offspring cardiovascular diseases later in life. The mechanisms involved are poorly understood, but epigenetic regulation of gene expression may play a part. We performed meta-analyses in the Pregnancy and Childhood Epigenetics Consortium to test the association between either maternal HDP (10 cohorts; n=5242 [cases=476]) or preeclampsia (3 cohorts; n=2219 [cases=135]) and epigenome-wide DNA methylation in cord blood using the Illumina HumanMethylation450 BeadChip. In models adjusted for confounders, and with Bonferroni correction, HDP and preeclampsia were associated with DNA methylation at 43 and 26 CpG sites, respectively. HDP was associated with higher methylation at 27 (63%) of the 43 sites, and across all 43 sites, the mean absolute difference in methylation was between 0.6% and 2.6%. Epigenome-wide associations of HDP with offspring DNA methylation were modestly consistent with the equivalent epigenome-wide associations of preeclampsia with offspring DNA methylation (R-2=0.26). In longitudinal analyses conducted in 1 study (n=108 HDP cases; 550 controls), there were similar changes in DNA methylation in offspring of those with and without HDP up to adolescence. Pathway analysis suggested that genes located at/near HDP-associated sites may be involved in developmental, embryogenesis, or neurological pathways. HDP is associated with offspring DNA methylation with potential relevance to development.

引用

页码：375 / 383

页数：9

共 50 条

[1] Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation: Findings From the Pregnancy and Childhood Epigenetics Consortium
Howe, Caitlin G.
Cox, Bianca
Fore, Ruby
Jungius, James
Kvist, Tuomas
Lent, Samantha
Miles, Harriet E.
Salas, Lucas A.
Rifas-Shiman, Sheryl
Starling, Anne P.
Yousefi, Paul
Ladd-Acosta, Christine
Baccarelli, Andrea
Binder, Elisabeth B.
Chatzi, Vaia Lida
Czamara, Darina
Dabelea, Dana
DeMeo, Dawn L.
Ghantous, Akram
Herceg, Zdenko
Kajantie, Eero
Lahti, Jari M. T.
Lawlor, Debbie A.
Litonjua, Augusto
Nawrot, Tim S.
Nohr, Ellen A.
Oken, Emily
Pizzi, Costanza
Plusquin, Michelle
Raeikkoenen, Katri
Relton, Caroline L.
Sharp, Gemma C.
Sorensen, Thorkild I. A.
Sunyer, Jordi
Vrijheid, Martine
Zhang, Weiming
Hivert, Marie-France
Breton, Carrie V.
DIABETES CARE, 2020, 43 (01) : 98 - 105
[2] Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium
Sharp, Gemma C.
Salas, Lucas A.
Monnereau, Claire
Allard, Catherine
Yousefi, Paul
Everson, Todd M.
Bohlin, Jon
Xu, Zongli
Huang, Rae-Chi
Reese, Sarah E.
Xu, Cheng-Jian
Baiz, Nour
Hoyo, Cathrine
Agha, Golareh
Roy, Ritu
Holloway, John W.
Ghantous, Akram
Merid, Simon K.
Bakulski, Kelly M.
Kupers, Leanne K.
Zhang, Hongmei
Richmond, Rebecca C.
Page, Christian M.
Duijts, Liesbeth
Lie, Rolv T.
Melton, Phillip E.
Vonk, Judith M.
Nohr, Ellen A.
Williams-DeVane, ClarLynda
Huen, Karen
Rifas-Shiman, Sheryl L.
Ruiz-Arenas, Carlos
Gonseth, Semira
Rezwan, Faisal I.
Herceg, Zdenko
Ekstrom, Sandra
Croen, Lisa
Falahi, Fahimeh
Perron, Patrice
Karagas, Margaret R.
Quraishi, Bilal M.
Suderman, Matthew
Magnus, Maria C.
Jaddoe, Vincent W. V.
Taylor, Jack A.
Anderson, Denise
Zhao, Shanshan
Smit, Henriette A.
Josey, Michele J.
Bradman, Asa
HUMAN MOLECULAR GENETICS, 2017, 26 (20) : 4067 - 4085
[3] Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium
Ronkainen, Justiina
Heiskala, Anni
Vehmeijer, Florianne O. L.
Lowry, Estelle
Caramaschi, Doretta
Estrada Gutierrez, Guadalupe
Heiss, Jonathan A.
Hummel, Nadine
Keikkala, Elina
Kvist, Tuomas
Kupsco, Allison
Melton, Phillip E.
Pesce, Giancarlo
Soomro, Munawar H.
Vives-Usano, Marta
Baiz, Nour
Binder, Elisabeth
Czamara, Darina
Guxens, Monica
Mustaniemi, Sanna
London, Stephanie J.
Rauschert, Sebastian
Vaarasmaki, Marja
Vrijheid, Martine
Ziegler, Anette-G.
Annesi-Maesano, Isabella
Bustamante, Mariona
Huang, Rae-Chi
Hummel, Sandra
Just, Allan C.
Kajantie, Eero
Lahti, Jari
Lawlor, Deborah
Raikkonen, Katri
Jarvelin, Marjo-Riitta
Felix, Janine F.
Sebert, Sylvain
EPIGENETICS, 2022, 17 (01) : 19 - 31
[4] Maternal hypertensive disorders of pregnancy and electrocardiographic findings in newborns
Noerskov, E. H.
Paerregaard, M. M.
Raja, A. A.
Sillesen, A. S.
Christiansen, A. H.
Boyd, H. A.
Bundgaard, H.
Iversen, K. K.
Voegg, R. O. B.
EUROPEAN HEART JOURNAL, 2023, 44
[5] Epigenome-Wide Consortium Meta-Analysis Of Dna Methylation And Childhood Asthma: The Pregnancy And Childhood Epigenetics (pace) Consortium
Reese, S. E.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195
[6] Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium
Wang, Siwen
Casey, Emma
Sordillo, Joanne
Aguilar-Lacasana, Sofia
Berstein, Fernanda Morales
Biedrzycki, Richard J.
Brescianini, Sonia
Chen, Su
Hough, Amy
Isaevska, Elena
Kim, Woo Jin
Lecorguille, Marion
Li, Sebastian Shaobo
Page, Christian M.
Park, Jaehyun
Roeder, Stefan
Salontaji, Kristina
Santorelli, Gillian
Sun, Yidan
Won, Sungho
Zillich, Eric
Zillich, Lea
Annesi-Maesano, Isabella
Arshad, S. Hasan
Bustamante, Mariona
Cecil, Charlotte A. M.
Elliott, Hannah R.
Ewart, Susan
Felix, Janine F.
Gagliardi, Luigi
Haberg, Siri E.
Herberth, Gunda
Heude, Barbara
Holloway, John W.
Huels, Anke
Karmaus, Wilfried
Koppelman, Gerard H.
London, Stephanie J.
Mumford, Sunni L.
Nistico, Lorenza
Popovic, Maja
Rusconi, Franca
Schisterman, Enrique F.
Stein, Dan J.
Send, Tabea
Tiemeier, Henning
Vonk, Judith M.
Vrijheid, Martine
Wiemels, Joseph Leo
Witt, Stephanie H.
SCIENCE ADVANCES, 2024, 10 (48):
[7] Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium
Felix, Janine F.
Joubert, Bonnie R.
Baccarelli, Andrea A.
Sharp, Gemma C.
Almqvist, Catarina
Annesi-Maesano, Isabella
Arshad, Hasan
Baiz, Nour
Bakermans-Kranenburg, Marian J.
Bakulski, Kelly M.
Binder, Elisabeth B.
Bouchard, Luigi
Breton, Carrie V.
Brunekreef, Bert
Brunst, Kelly J.
Burchard, Esteban G.
Bustamante, Mariona
Chatzi, Leda
Munthe-Kaas, Monica Cheng
Corpeleijn, Eva
Czamara, Darina
Dabelea, Dana
Smith, George Davey
De Boever, Patrick
Duijts, Liesbeth
Dwyer, Terence
Eng, Celeste
Eskenazi, Brenda
Everson, Todd M.
Falahi, Fahimeh
Fallin, M. Daniele
Farchi, Sara
Fernandez, Mariana F.
Gao, Lu
Gaunt, Tom R.
Ghantous, Akram
Gillman, Matthew W.
Gonseth, Semira
Grote, Veit
Gruzieva, Olena
Haberg, Siri E.
Herceg, Zdenko
Hivert, Marie-France
Holland, Nina
Holloway, John W.
Hoyo, Cathrine
Hu, Donglei
Huang, Rae-Chi
Huen, Karen
Jarvelin, Marjo-Riitta
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2018, 47 (01) : 22 - +
[8] Laboratory findings in hypertensive disorders of pregnancy
FitzGerald, MP
Floro, C
Siegel, J
Hernandez, E
JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION, 1996, 88 (12) : 794 - 798
[9] Hypertensive Disorders of Pregnancy and Childhood Growth
Gyamfi-Bannerman, Cynthia
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2024, 230 (01) : S375 - S376
[10] Hypertensive epigenetics: from DNA methylation to microRNAs
J Wang
L Gong
Y Tan
R Hui
Y Wang
Journal of Human Hypertension, 2015, 29 : 575 - 582

← 1 2 3 4 5 →