Epicardial Fat Thickness Correlates With Carotid Intima-Media Thickness, Arterial Stiffness, and Cardiac Geometry in Children and Adolescents

被引:35
|
作者
Oscar Cabrera-Rego, Julio [1 ]
Iacobellis, Gianluca [2 ]
Arcides Castillo-Herrera, Jose [3 ]
Valiente-Mustelier, Juan [4 ]
Gandarilla-Sarmientos, Julio C. [4 ]
Maria Marin-Julia, Silvia [5 ]
Navarrete-Cabrera, Juliette [5 ]
机构
[1] Hosp Manuel Fajardo, Dept Cardiol, Havana, Cuba
[2] Univ Miami, Miller Sch Med, Div Diabet Endocrinol & Metab, Dept Med, Miami, FL 33136 USA
[3] Hosp Manuel Fajardo, Havana, Cuba
[4] Natl Inst Cardiol & Cardiovasc Surg, Echocardiog Dept, Havana, Cuba
[5] Natl Inst Endocrinol, Pediat Endocrinol Dept, Havana, Cuba
关键词
Epicardial fat; Atherosclerosis; Obesity; ADIPOSE-TISSUE; CARDIOVASCULAR EVENTS; EARLY ATHEROSCLEROSIS; VISCERAL ADIPOSITY; OBESE CHILDREN; WEIGHT-LOSS; POPULATION; PREDICTION; VALUES;
D O I
10.1007/s00246-013-0799-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To determine the association between epicardial fat thickness and carotid arterial stiffness, carotid intima-media thickness (CMIT), left atrial (LA) volume, and left-ventricular (LV) geometry parameters in obese children and adolescents compared with controls. A case-control study was performed in 96 children and adolescents (obese n = 66, controls n = 30) age 9-16 years old (38 female and 58 male, mean age 11.7 +/- A 2.8 years) undergoing transthoracic echocardiography and carotid artery ultrasound. Clinical, anthropometric, and biochemical determinations were also recorded. Epicardial fat thickness (2.76 +/- A 1.2 vs. 1.36 +/- A 0.7 mm, p < 0.001), LA volume (35.7 +/- A 13.2 vs. 28.9 +/- A 9.8 mL, p = 0.008), LV mass (118.3 +/- A 38.6 vs. 96.4 +/- A 35.4 mL, p = 0.008), CIMT (0.48 +/- A 0.07 vs. 0.44 +/- A 0.05 mm, p = 0.019), and local pulse wave velocity (LPWV; 3.7 +/- A 0.5 vs. 3.2 +/- A 0.4 m/seg, p = 0.007) were significantly increased in obese children and adolescents compared with controls. Epicardial fat showed a significant and positive correlation with LA volume, LV mass, and LPWV as well as a significant and independent association with increased CIMT (odds ratio (OR) = 3.19 [1.88-7.99], p = 0.005) in the study population. Epicardial fat thickness is linked to obesity, carotid subclinical atherosclerosis, and cardiac geometry parameters and might be a useful tool for the cardiovascular risk stratification in children and adolescents.
引用
收藏
页码:450 / 456
页数:7
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