Sentinel Lymph Node Biopsy in Breast Cancer

被引:56
|
作者
Manca, Gianpiero [1 ]
Rubello, Domenico [2 ]
Tardelli, Elisa [1 ]
Giammarile, Francesco [3 ]
Mazzarri, Sara [1 ]
Boni, Giuseppe [1 ]
Chondrogiannis, Sotirios [2 ]
Marzola, Maria Cristina [2 ]
Chiacchio, Serena [1 ]
Ghilli, Matteo [4 ]
Roncella, Manuela [4 ]
Volterrani, Duccio [1 ]
Colletti, Patrick M. [5 ]
机构
[1] Hosp Univ Pisa, Reg Ctr Nucl Med, Pisa, Italy
[2] S Maria della Misericordia Hosp, Dept Nucl Med, Rovigo, Italy
[3] Hosp Civils Lyon, Med Nucl, Fac Med Lyon Sud, Biophys, Lyon, France
[4] Hosp Univ Pisa, Unit Senol, Pisa, Italy
[5] Univ So Calif, Dept Radiol, Los Angeles, CA USA
关键词
sentinel lymph node; breast cancer; indications; radiopharmaceuticals; INTERNAL MAMMARY NODES; CARCINOMA IN-SITU; NEOADJUVANT SYSTEMIC THERAPY; EXTENDED RADICAL-MASTECTOMY; RANDOMIZED CLINICAL-TRIAL; GAMMA-PROBE DETECTION; FALSE-NEGATIVE RATES; AXILLARY DISSECTION; RADIOGUIDED SURGERY; CONSENSUS CONFERENCE;
D O I
10.1097/RLU.0000000000000985
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Axillary lymph node status, a major prognostic factor in early-stage breast cancer, provides information important for individualized surgical treatment. Because imaging techniques have limited sensitivity to detect metastasis in axillary lymph nodes, the axilla must be explored surgically. The histology of all resected nodes at the time of axillary lymph node dissection (ALND) has traditionally been regarded as the most accurate method for assessing metastatic spread of disease to the locoregional lymph nodes. However, ALND may result in lymphedema, nerve injury, shoulder dysfunction, and other short-term and long-term complications limiting functionality and reducing quality of life. Sentinel lymph node biopsy (SLNB) is a less invasive method of assessing nodal involvement. The concept of SLNB is based on the notion that tumors drain in an orderly manner through the lymphatic system. Therefore, the SLN is the first to be affected by metastasis if the tumor has spread, and a tumor-free SLN makes it highly unlikely for other nodes to be affected. Sentinel lymph node biopsy has become the standard of care for primary treatment of early breast cancer and has replaced ALND to stage clinically node-negative patients, thus reducing ALND-associated morbidity. More than 20 years after its introduction, there are still aspects concerning SLNB and ALND that are currently debated. Moreover, SLNB remains an unstandardized procedure surrounded by many unresolved controversies concerning the technique itself. In this article, we review themain indications, contraindications, and controversies of SLNB in breast cancer in the light of the most recent publications.
引用
收藏
页码:126 / 133
页数:8
相关论文
共 50 条
  • [1] The sentinel lymph node biopsy in breast cancer
    Weerts, JM
    Maweja, S
    Tamigneaux, I
    Dallemagne, B
    Jourdan, JL
    Markiewicz, S
    Monami, B
    Wahlen, C
    Lastra, M
    Hénon, V
    Gomez, P
    Lilet, H
    Dwelshauwers, J
    Graas, MP
    Focan, C
    Lipczei, B
    Abraham, F
    Jehaes, C
    [J]. ACTA CHIRURGICA BELGICA, 2002, 102 (02) : 110 - 113
  • [2] Sentinel lymph node biopsy in breast cancer
    Alsaif, Abdulaziz A.
    [J]. SAUDI MEDICAL JOURNAL, 2015, 36 (09) : 1053 - 1060
  • [3] Sentinel lymph node biopsy in breast cancer
    Sakorafas, GH
    Tsiotou, AG
    [J]. AMERICAN SURGEON, 2000, 66 (07) : 667 - 674
  • [4] Sentinel lymph node biopsy in breast cancer
    Dowling, CM
    Hill, ADK
    [J]. SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND, 2004, 2 (05): : 273 - 276
  • [5] Sentinel lymph node biopsy and breast cancer
    Noguchi, M
    [J]. BRITISH JOURNAL OF SURGERY, 2002, 89 (01) : 21 - 34
  • [6] Sentinel lymph node biopsy in breast cancer
    Bonnema, J
    van de Velde, CJH
    [J]. ANNALS OF ONCOLOGY, 2002, 13 (10) : 1531 - 1537
  • [7] Sentinel lymph node biopsy in breast cancer
    Luschin, Gero
    [J]. WIENER MEDIZINISCHE WOCHENSCHRIFT, 2010, 160 (19-20) : 497 - 500
  • [8] Sentinel lymph node biopsy in breast cancer
    Rody, A
    Solbach, C
    Kaufmann, M
    [J]. CHIRURG, 2004, 75 (08): : 767 - 773
  • [9] Sentinel lymph node biopsy and breast cancer
    Govender, S
    [J]. ANZ JOURNAL OF SURGERY, 2004, 74 (04) : 287 - 287
  • [10] Sentinel lymph node biopsy for breast cancer
    Sato, K.
    Shigenaga, R.
    Ueda, S.
    Shigekawa, T.
    Krag, D. N.
    [J]. JOURNAL OF SURGICAL ONCOLOGY, 2007, 96 (04) : 322 - 329