Occupational HIV Infection in a Research Laboratory With Unknown Mode of Transmission: A Case Report

被引：5

作者：

Soria, Alessandro ^{[1
]}

Alteri, Claudia ^{[2
]}

Scarlatti, Gabriella ^{[3
]}

Bertoli, Ada ^{[2
]}

Tolazzi, Monica ^{[3
]}

Balestra, Emanuela ^{[2
]}

Bellocchi, Maria Concetta ^{[2
]}

Continenza, Fabio ^{[4
]}

Carioti, Luca ^{[2
]}

Biasin, Mara ^{[5
]}

Trabattoni, Daria ^{[5
]}

Bandera, Alessandra ^{[1
]}

Ceccherini-Silberstein, Francesca ^{[2
]}

Perno, Carlo Federico ^{[2
]}

Gori, Andrea ^{[1
]}

机构：

[1] Univ Milano Bicocca, San Gerardo Hosp, Div Infect Dis, Monza, Italy

[2] Univ Roma Tor Vergata, Dept Expt Med & Surg, Milan, Italy

[3] Ist Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Viral Evolut & Transmiss Unit, Milan, Italy

[4] IRCCS, Natl Inst Infect Dis L Spallanzani, Rome, Italy

[5] Univ Milan, Dept Biomed & Clin Sci L Sacco, I-20122 Milan, Italy

来源：

CLINICAL INFECTIOUS DISEASES | 2017年 / 64卷 / 06期

关键词：

HIV-1; occupational exposure; laboratory safety; HIV transmission; HUMAN-IMMUNODEFICIENCY-VIRUS; VESICULAR STOMATITIS-VIRUS; LENTIVIRAL VECTORS;

D O I：

10.1093/cid/ciw851

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A laboratory worker was infected with human immunodeficiency virus (HIV) type 1 in a biosafety level 2 containment facility, without any apparent breach. Through full-genome sequencing and phylogenetic analyses, we could identify the source of infection in a replication-competent clone that unknowingly contaminated a safe experiment. Mode of transmission remains unclear. Caution is warranted when handling HIV-derived constructs.

引用

页码：810 / 813

页数：4

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