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- [1] Preclinical characterization of the selective DNA-dependent protein kinase (DNA-PK) inhibitor VX-984 in combination with chemotherapyANNALS OF ONCOLOGY, 2016, 27Boucher, D.论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Res, Boston, MA USA Vertex Pharmaceut Inc, Res, Boston, MA USAHillier, S.论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Res, Boston, MA USA Vertex Pharmaceut Inc, Res, Boston, MA USANewsome, D.论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Res, Boston, MA USA Vertex Pharmaceut Inc, Res, Boston, MA USAWang, Y.论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Res, Boston, MA USA Vertex Pharmaceut Inc, Res, Boston, MA USATakemoto, D.论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Res, Boston, MA USA Vertex Pharmaceut Inc, Res, Boston, MA USAGu, Y.论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Res, Boston, MA USA Vertex Pharmaceut Inc, Res, Boston, MA USAMarkland, W.论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Res, Boston, MA USA Vertex Pharmaceut Inc, Res, Boston, MA USAHoover, R.论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Res, Boston, MA USA Vertex Pharmaceut Inc, Res, Boston, MA USAArimoto, R.论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Res, Boston, MA USA Vertex Pharmaceut Inc, Res, Boston, MA USAMaxwell, J.论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Chem, Boston, MA USA Vertex Pharmaceut Inc, Res, Boston, MA USAFields, S. Z.论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Clin Dev, Boston, MA USA Vertex Pharmaceut Inc, Res, Boston, MA USACharifson, P.论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Res, Boston, MA USA Vertex Pharmaceut Inc, Res, Boston, MA USAPenney, M. S.论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Discovery Biomarkers, Boston, MA USA Vertex Pharmaceut Inc, Res, Boston, MA USATanner, K.论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Res, Boston, MA USA Vertex Pharmaceut Inc, Res, Boston, MA USA
- [2] Discovery of VX-984: A novel, selective DNA-PK inhibitor for the treatment of cancerABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251Maxwell, John论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USACottrell, Kevin论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAXu, Jinwang论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAArimoto, Rieko论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USABoucher, Brian论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAChandupatla, Kishan论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USACochran, John论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USADamagnez, Veronique论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAEngtrakul, Juntyma论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAFord, Pamella论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAFurey, Brinley论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAGiroux, Simon论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAGreen, Jeremy论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAHenry, Larry论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAHillier, Shawn论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAHogan, James论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAHoover, Russell论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAJackson, Katrina论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAMarkland, William论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAMoody, Cameron论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAMorris, Mark论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAPierce, Albert论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAShannon, Dean论文数: 0 引用数: 0 h-index: 0机构: DE Synthet, Fredericton, NB, Canada Vertex Pharmaceut Inc, Boston, MA USAStearns, Ralph论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAWaal, Nathan论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAWang, Yuxin论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USAWood, Mark论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USABoucher, Diane论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USACharifson, Paul论文数: 0 引用数: 0 h-index: 0机构: Vertex Pharmaceut Inc, Boston, MA USA Vertex Pharmaceut Inc, Boston, MA USA
- [3] The DNA-PK Inhibitor VX-984 Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and as Orthotopic XenograftsMOLECULAR CANCER THERAPEUTICS, 2018, 17 (06) : 1207 - 1216Timme, Cindy R.论文数: 0 引用数: 0 h-index: 0机构: NCI, Radiat Oncol Branch, Bldg 10, Bethesda, MD 20892 USA NCI, Radiat Oncol Branch, Bldg 10, Bethesda, MD 20892 USARath, Barbara H.论文数: 0 引用数: 0 h-index: 0机构: NCI, Radiat Oncol Branch, Bldg 10, Bethesda, MD 20892 USA NCI, Radiat Oncol Branch, Bldg 10, Bethesda, MD 20892 USAO'Neill, Johnw.论文数: 0 引用数: 0 h-index: 0机构: NCI, Radiat Oncol Branch, Bldg 10, Bethesda, MD 20892 USA NCI, Radiat Oncol Branch, Bldg 10, Bethesda, MD 20892 USACamphausen, Kevin论文数: 0 引用数: 0 h-index: 0机构: NCI, Radiat Oncol Branch, Bldg 10, Bethesda, MD 20892 USA NCI, Radiat Oncol Branch, Bldg 10, Bethesda, MD 20892 USATofilon, Philip J.论文数: 0 引用数: 0 h-index: 0机构: NCI, Radiat Oncol Branch, Bldg 10, Bethesda, MD 20892 USA NCI, Radiat Oncol Branch, Bldg 10, Bethesda, MD 20892 USA
- [4] Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeineNUCLEIC ACIDS RESEARCH, 2004, 32 (06) : 1967 - 1972Block, WD论文数: 0 引用数: 0 h-index: 0机构: Univ Calgary, Dept Biol Sci, Canc Biol Res Grp, Calgary, AB T2N 4N1, CanadaMerkle, D论文数: 0 引用数: 0 h-index: 0机构: Univ Calgary, Dept Biol Sci, Canc Biol Res Grp, Calgary, AB T2N 4N1, CanadaMeek, K论文数: 0 引用数: 0 h-index: 0机构: Univ Calgary, Dept Biol Sci, Canc Biol Res Grp, Calgary, AB T2N 4N1, CanadaLees-Miller, SP论文数: 0 引用数: 0 h-index: 0机构: Univ Calgary, Dept Biol Sci, Canc Biol Res Grp, Calgary, AB T2N 4N1, Canada
- [5] Development of potent inhibitors of the DNA-dependent protein kinase (DNA-PK)CANCER RESEARCH, 2010, 70Cano, Celine论文数: 0 引用数: 0 h-index: 0Bailey, Chris论文数: 0 引用数: 0 h-index: 0Bardos, Julia论文数: 0 引用数: 0 h-index: 0Curtin, Nicola论文数: 0 引用数: 0 h-index: 0Frigerio, Mark论文数: 0 引用数: 0 h-index: 0Golding, Bernard论文数: 0 引用数: 0 h-index: 0Hardcastle, Ian论文数: 0 引用数: 0 h-index: 0Hummersone, Marc论文数: 0 引用数: 0 h-index: 0Menear, Keith论文数: 0 引用数: 0 h-index: 0Newell, David论文数: 0 引用数: 0 h-index: 0Saravanan, Kappusamy论文数: 0 引用数: 0 h-index: 0Shea, K.论文数: 0 引用数: 0 h-index: 0Smith, Graeme论文数: 0 引用数: 0 h-index: 0Griffin, Roger论文数: 0 引用数: 0 h-index: 0
- [6] Development of potent inhibitors of the DNA-dependent protein kinase (DNA-PK)MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)Cano, Celine论文数: 0 引用数: 0 h-index: 0Curtin, Nicola论文数: 0 引用数: 0 h-index: 0Hardcastle, Ian论文数: 0 引用数: 0 h-index: 0Golding, Bernard论文数: 0 引用数: 0 h-index: 0Smith, Graeme论文数: 0 引用数: 0 h-index: 0Newell, Herbie论文数: 0 引用数: 0 h-index: 0Griffin, Roger论文数: 0 引用数: 0 h-index: 0
- [7] Development of potent inhibitors of DNA-dependent protein kinase (DNA-PK)ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245Barrett, Lauren论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandRennison, Tommy论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandClapham, Kate M.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandRodriguez-Aristegui, Sonsoles论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandBardos, Julia论文数: 0 引用数: 0 h-index: 0机构: KuDOS Pharmaceut Ltd, Cambridge CB4 0PE, Cambs, England Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandCurtin, Nicola J.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandDennis, M.论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Alderley Pk SK10 4TF, Cheshire, England Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandFinlay, Ray论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Alderley Pk SK10 4TF, Cheshire, England Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandGolding, Bernard T.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandHardcastle, Ian R.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandNewell, David R.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandYoung, Gail论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Alderley Pk SK10 4TF, Cheshire, England Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandCano, Celine论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandGriffin, Roger J.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Northern Inst Canc Res, Newcastle Canc Ctr, Dept Drug Discovery, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
- [8] Development of potent inhibitors of DNA-dependent protein kinase (DNA-PK)EJC SUPPLEMENTS, 2010, 8 (07): : 140 - 140Clapham, K. M.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandRennison, T.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandRodriguez-Aristegui, S.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandBardos, J.论文数: 0 引用数: 0 h-index: 0机构: KuDOS Pharmaceut Ltd, Cambridge, England Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandCurtin, N. J.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandGolding, B. T.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandHardcastle, I. R.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandNewell, D. R.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandCano, C.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, EnglandGriffin, R. J.论文数: 0 引用数: 0 h-index: 0机构: Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Newcastle Univ, Newcastle Canc Ctr, No Inst Canc Res, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
- [9] DNA-BINDING BY THE THE HUMAN DNA-DEPENDENT PROTEIN-KINASE, DNA-PKFASEB JOURNAL, 1995, 9 (06): : A1394 - A1394POLTORATSKY, V论文数: 0 引用数: 0 h-index: 0机构: ST JOHNS UNIV, DEPT BIOL SCI, JAMAICA, NY 11439 USAMALIK, N论文数: 0 引用数: 0 h-index: 0机构: ST JOHNS UNIV, DEPT BIOL SCI, JAMAICA, NY 11439 USASAMSON, G论文数: 0 引用数: 0 h-index: 0机构: ST JOHNS UNIV, DEPT BIOL SCI, JAMAICA, NY 11439 USALIEBER, M论文数: 0 引用数: 0 h-index: 0机构: ST JOHNS UNIV, DEPT BIOL SCI, JAMAICA, NY 11439 USACARTER, T论文数: 0 引用数: 0 h-index: 0机构: ST JOHNS UNIV, DEPT BIOL SCI, JAMAICA, NY 11439 USA
- [10] A novel, selective inhibitor of DNA-dependent protein kinase (DNA-PK) potentiates the effects of DNA-damaging therapies in hepatocellular carcinomaCANCER RESEARCH, 2017, 77Willoughby, Catherine E.论文数: 0 引用数: 0 h-index: 0Thomas, Huw D.论文数: 0 引用数: 0 h-index: 0Rennison, Tommy论文数: 0 引用数: 0 h-index: 0Cano, Celine论文数: 0 引用数: 0 h-index: 0Reeves, Helen L.论文数: 0 引用数: 0 h-index: 0Wedge, Stephen R.论文数: 0 引用数: 0 h-index: 0