Importance of media composition in the study of metabolic clearance when using rat hepatocytes in suspension

被引:0
|
作者
Leandersson, Sara I. M. [1 ]
Rehngren, Mikael [1 ]
Projean, Denis [1 ]
机构
[1] AstraZeneca R&D, Dx DMPK & BAC, Molndal, Sweden
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
220
引用
收藏
页码:142 / 143
页数:2
相关论文
共 50 条
  • [1] COMPARISON OF CLEARANCE AND METABOLIC PATHWAYS IN SUSPENSION HEPATOCYTES AND HEPATOPAC CULTURES
    Liu, Joyce
    Cai, Jingwei
    Wong, Susan
    DRUG METABOLISM AND PHARMACOKINETICS, 2024, 55
  • [2] IN VITRO EVALUATION OF RAT HEPATIC METABOLIC CLEARANCE USING FRESHLY ISOLATED RAT PLATED HEPATOCYTES
    Lai, Jing
    Yang, Ning
    Zhang, Sicong
    Li, Xiaoxue
    Yang, Youpeng
    Zhang, Hong
    Jia, Junru
    Du, Hongwen
    Zhang, Shaofeng
    Li, Chen
    Wen, Yuncan
    Jones, Barry
    DRUG METABOLISM AND PHARMACOKINETICS, 2024, 55
  • [3] Influence of media composition and incubation conditions on troglitazone metabolism in fresh and cryopreserved rat hepatocytes in suspension
    Leandersson, Sara
    Jurva, Ulrik
    Olsen, Jorgen
    Berglund, Camilla
    DRUG METABOLISM REVIEWS, 2006, 38 : 145 - 145
  • [4] Cryopreserved human hepatocytes in suspension are a convenient high throughput tool for the prediction of metabolic clearance
    Jouin, Delphine
    Blanchard, Nadege
    Alexandre, Eliane
    Delobel, Frederic
    David-Pierson, Pascale
    Lave, Thierry
    Jaeck, Daniel
    Richert, Lysiane
    Coassolo, Philippe
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2006, 63 (03) : 347 - 355
  • [5] A new in vitro method to predict in vivo human and rat metabolic availability by using a suspension of cryopreserved hepatocytes in diluted plasma
    Junges, C
    Bonamy, K
    Bertrand, M
    DRUG METABOLISM REVIEWS, 2005, 37 : 50 - 50
  • [6] Prediction of metabolic clearance using fresh human hepatocytes: Comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines
    Hallifax, D.
    Galetin, A.
    Houston, J. B.
    XENOBIOTICA, 2008, 38 (04) : 353 - 367
  • [7] THE IMPORTANCE OF PH IN RESUSPENSION MEDIA ON VIABILITY OF RAT HEPATOCYTES PRESERVED IN COLD LACTOBIONATE SOLUTIONS
    MAMPRIN, ME
    RODRIGUEZ, JV
    GUILBERT, EE
    HEPATOLOGY, 1994, 19 (04) : I96 - I96
  • [8] Prediction of metabolic clearance using cryopreserved human hepatocytes: Kinetic characteristics for five benzodiazepines
    Hallifax, D
    Rawden, HC
    Hakooz, N
    Houston, JB
    DRUG METABOLISM AND DISPOSITION, 2005, 33 (12) : 1852 - 1858
  • [9] Metabolic changes in hepatocytes during HCV infection: a study in the physiological media
    Golikov, M.
    Zakirova, N.
    Karpenko, I.
    Smirnova, O.
    Ivanov, A.
    FEBS OPEN BIO, 2021, 11 : 372 - 372
  • [10] In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human Hepatocytes
    Luca Docci
    Florian Klammers
    Aynur Ekiciler
    Birgit Molitor
    Kenichi Umehara
    Isabelle Walter
    Stephan Krähenbühl
    Neil Parrott
    Stephen Fowler
    The AAPS Journal, 22