Presenilin 1 is essential for cardiac morphogenesis

被引：37
|
作者：
Nakajima, M
Moriizumi, E
Koseki, H
Shirasawa, T
机构：
[1] Tokyo Metropolitan Inst Gerontol, Dept Mol Gerontol, Itabashi Ku, Tokyo 1730015, Japan
[2] Chiba Univ, Grad Sch Med, Dept Mol Embryol, Chuo Ku, Chiba, Japan
来源：
DEVELOPMENTAL DYNAMICS | 2004年 / 230卷 / 04期
关键词：
presenilin; 1; heart; cardiac morphogenesis; pulmonary stenosis; double outlet right ventricle; ventricular septal defect;
D O I：
10.1002/dvdy.20098
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Presenilin 1 (PSI) is the gene responsible for the development of early-onset familial Alzheimer's disease. PS1-deficient mice have been reported to show defects in neurogenesis, somitogenesis and angiogenesis. Here, we report cardiac anomaly in PS1-deficient mice: the mutant hearts exhibited ventricular septal defect, double outlet right ventricle, and stenosis in the pulmonary artery. Immunohistochemistry using anti-PS1 antibody revealed the prominent expression of PSI in mesenchymal cells at the septal area of the wild-type heart. These results suggest that PSI may play an essential role in heart development. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码：795 / 799
页数：5
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