Fatigue and daytime sleepiness in patients with myotonic dystrophy type 1: To lump or split?

被引：48
|
作者：
Laberge, Luc [1 ,2 ,3 ]
Dauvilliers, Yves [4 ]
Begin, Paul [3 ]
Richer, Louis [1 ]
Jean, Stephane [5 ]
Mathieu, Jean [5 ]
机构：
[1] Univ Quebec, Dept Sci Educ & Psychol, Chicoutimi, PQ G7H 2B1, Canada
[2] ECOBES, Jonquiere, PQ, Canada
[3] Ctr Hosp Affilie Univ Reg CAUR Chicoutimi, Ctr Sante & Serv Sociaux Chicoutimi, Chicoutimi, PQ, Canada
[4] Univ Montpellier 1, INSERM, CHU Montpellier, Serv Neurol,U888, F-34006 Montpellier, France
[5] Ctr Sante & Serv Sociaux Jonquiere, Clin Malad Neuromusculaires, Chicoutimi, PQ, Canada
来源：
NEUROMUSCULAR DISORDERS | 2009年 / 19卷 / 06期
基金：
加拿大健康研究院;
关键词：
Myotonic dystrophy; Fatigue; Hypersomnia; Personality; Depressive symptoms; IQ; Health-related quality of life (HRQoL); FACIOSCAPULOHUMERAL DYSTROPHY; NEUROLOGICAL DISORDERS; MULTIPLE-SCLEROSIS; HMSN-I; SCALE; HYPERSOMNIA; SOMNOLENCE; RELIABILITY; MODAFINIL; TIREDNESS;
D O I：
10.1016/j.nmd.2009.03.007
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We assessed the relationship and clinical correlates of fatigue and Excessive Daytime Sleepiness (EDS) in 200 myotonic dystrophy type 1 (DM1) patients by means of questionnaire and neuropsychological evaluation. Fatigue levels were higher in patients with EDS and daytime sleepiness levels higher in patients with excessive fatigue. However, EDS without fatigue was rarely observed. Also, DM1 patients with fatigue (with or without EDS) showed greater Muscular impairment, CTG repeats, abnormalities regarding personality, depressive symptoms and lower health-related quality of life (HRQoL) than patients without these symptoms. These findings do not readily support the contention that fatigue and EDS constitute distinct clinical manifestations in DM1. Clinicians should systematically evaluate both symptoms since fatigue and EDS have a greater impact on HRQoL than fatigue alone. However, specific rating scales for fatigue in DM1 have yet to be devised. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：397 / 402
页数：6
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