Zinc-deficient rats are insensitive to glucoprivation caused by 2-deoxy-D-glucose

被引:3
|
作者
Cole, AC
Shay, NF
O'Brien, S
Beverly, JL
机构
[1] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA
[2] Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA
[3] Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USA
关键词
zinc deficiency; anorexia; glucoprivation; rat; food intake regulation;
D O I
10.1080/10284150290007092
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Three-choice macronutrient intake studies indicate that zinc-deficient (Zn-) rats selectively decrease intake of carbohydrate. Because glucoprivic stimuli increase food intake and selection for carbohydrate, the ability of Zn- rats to respond to glucoprivation induced by 2-deoxy-D-glucose (2-DG) was tested. Rats were fed a Zn-adequate (Zn+) or Zn- diet. In part 1, rats were challenged with 0, 250, or 400 mg 2-DG/kg BW (i.p.) after zinc deficiency was established. In part 2, rats received saline or 2-DG while zinc deficiency was being induced and then after deficiency was established. Food intake was increased after injection of 2-DG to Zn+ rats; however, food intake was not higher after 2-DG administration to Zn- rats. A dose-response test for 2-DG further confirmed these results. In part 2, it was found that Zn- rats lose the response to 2-DG administration when zinc deficiency-induced anorexia begins, after 3 days of consuming a zinc-deficient diet. It appears that the ability to sense blood glucose concentrations may be impaired during zinc deficiency, and this impairment could be a part of the anorexia that develops during zinc deficiency in the rat.
引用
收藏
页码:59 / 64
页数:6
相关论文
共 50 条
  • [1] HYPOTHERMIA FROM 2-DEOXY-D-GLUCOSE (2DG) INDUCED GLUCOPRIVATION IN HUMANS
    THOMPSON, DA
    CAMPBELL, RG
    [J]. DIABETES, 1978, 27 : 507 - 507
  • [2] FAILURE OF RATS DEPRIVED OF WATER TO INCREASE FOOD-INTAKE DURING GLUCOPRIVATION INDUCED BY 2-DEOXY-D-GLUCOSE
    WATSON, PJ
    BIDERMAN, MD
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1982, 17 (05) : 955 - 959
  • [3] EFFECTS OF ANORECTIC DRUGS ON THE HYPERPHAGIC RESPONSE INDUCED BY INSULIN OR 2-DEOXY-D-GLUCOSE GLUCOPRIVATION
    CURRUBA, MO
    MANTEGAZZA, P
    MULLER, EE
    RICCIARDI, S
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1981, 72 (01) : P161 - P161
  • [4] Melatonin suppresses hyperglycemia caused by intracerebroventricular injection of 2-deoxy-D-glucose in rats
    Shima, T
    Chun, SJ
    Niijima, A
    BizotEspiard, JG
    GuardiolaLemaitre, B
    Hosokawa, M
    Nagai, K
    [J]. NEUROSCIENCE LETTERS, 1997, 226 (02) : 119 - 122
  • [5] EFFECTS OF 2-DEOXY-D-GLUCOSE ON THERMOREGULATION IN RATS
    FORICHON, J
    MOTTAZ, M
    JOMAIN, MJ
    MINAIRE, Y
    [J]. JOURNAL DE PHYSIOLOGIE, 1974, 68 (03): : 351 - 358
  • [6] Involvement of cerebral neurotensin in hyperglycemic response caused by 2-deoxy-D-glucose in rats
    Chun, SJ
    Niijima, A
    Shimizu, K
    Nagai, K
    [J]. NEUROSCIENCE LETTERS, 1995, 201 (03) : 191 - 194
  • [7] Metabolic responses to glucoprivation induced by 2-deoxy-D-glucose in Brycon cephalus (Teleostei, Characidae)
    M. L. Figueiredo-Garutti
    E. Capilla
    M. L. M. Vicentini-Paulino
    J. Gutiérrez
    R. H. S. Souza
    G. Moraes
    I. Navarro
    [J]. Journal of Comparative Physiology B, 2004, 174 : 91 - 96
  • [8] CENTRAL GLUCOPRIVATION - SOME PHYSIOLOGICAL EFFECTS INDUCED BY INTRAVENTRICULAR ADMINISTRATION OF 2-DEOXY-D-GLUCOSE
    MULLER, EE
    PANERAI, A
    COCCHI, D
    FROHMAN, LA
    MANTEGAZZA, P
    [J]. EXPERIENTIA, 1973, 29 (07): : 874 - 876
  • [9] Metabolic responses to glucoprivation induced by 2-deoxy-D-glucose in Brycon cephalus (Teleostei, Characidae)
    Figueiredo-Garutti, ML
    Capilla, E
    Vicentini-Paulino, MLM
    Gutiérrez, J
    Souza, RHS
    Moraes, G
    Navarro, I
    [J]. JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY, 2004, 174 (01): : 91 - 96
  • [10] GLUCOSE-TOLERANCE IN ZINC-DEFICIENT RATS
    HENDRICKS, DG
    MAHONEY, AW
    [J]. JOURNAL OF NUTRITION, 1972, 102 (08): : 1079 - +