Pd-Catalyzed Decarboxylative Cycloaddition for the Synthesis of Highly Substituted δ-Lactones and Lactams

被引：7

作者：

Shi, Linlin ^{[1
,2
]}

He, Yingdong ^{[1
]}

Gong, Jianxian ^{[1
]}

Yang, Zhen ^{[1
,3
,4
,5
]}

机构：

[1] Peking Univ, State Key Lab Chem Oncogen, Key Lab Chem Genom, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China

[2] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Henan, Peoples R China

[3] Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing 100871, Peoples R China

[4] Peking Univ, Beijing Natl Lab Mol Sci BNLMS, Beijing 100871, Peoples R China

[5] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China

来源：

ORGANOMETALLICS | 2021年 / 40卷 / 03期

基金：

美国国家科学基金会;

关键词：

Catalytic system - Cyclic carbonates - Cycloaddition process - Double bonds - Palladium-catalyzed - Regio-selective - Situ generation;

D O I：

10.1021/acs.organomet.0c00646

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient palladium-catalyzed decarboxylative cycloaddition process of vinyl cyclic carbonates and vinyl-oxazolidinones for the synthesis of highly substituted delta-lactone and delta-lactam derivatives was developed. This protocol exhibits several unique characteristics, including broad substrate scope, good functional group tolerance, and operational convenience, which enables a regioselective access to a variety of lactone and lactam scaffolds in moderate to good yield. The redox-neutral catalytic system promotes formation of substituted scaffolds with in situ generation of a cyclic tetra-substituted double bond functionality.

引用

页码：324 / 332

页数：9

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