Therapeutic Potential of Targeting Wnt/-Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress

被引：131
|
作者：
Bahrami, Afsane [1 ]
Amerizadeh, Forouzan [1 ]
ShahidSales, Soodabeh [4 ]
Khazaei, Majid [5 ]
Ghayour-Mobarhan, Majid [4 ]
Sadeghnia, Hamid Reza [1 ]
Maftouh, Mina [3 ]
Hassanian, Seyed Mahdi [2 ,3 ]
Avan, Amir [3 ,4 ]
机构：
[1] Mashhad Univ Med Sci, Fac Med, Dept Modern Sci & Technol, Mashhad, Iran
[2] Mashhad Univ Med Sci, Sch Med, Dept Med Biochem, Mashhad, Iran
[3] Mashhad Univ Med Sci, Sch Med, Metab Syndrome Res Ctr, Mashhad, Iran
[4] Mashhad Univ Med Sci, Sch Med, Canc Res Ctr, Mashhad, Iran
[5] Mashhad Univ Med Sci, Neurogen Inflammatory Res Ctr, Dept Physiol, Mashhad, Iran
来源：
JOURNAL OF CELLULAR BIOCHEMISTRY | 2017年 / 118卷 / 08期
关键词：
COLON CANCER; Wnt; -CATENIN; INHIBITOR; THERAPEUTIC TARGET; SMALL-MOLECULE INHIBITOR; BETA-CATENIN; COLON-CANCER; STEM-CELLS; SIGNALING PATHWAY; PDZ DOMAIN; E-CADHERIN; ACTIVATION; EXPRESSION; DIFFERENTIATION;
D O I：
10.1002/jcb.25903
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Wnt/-catenin pathway is one of the main/frequent dysregulated pathways in several tumor types, including colon cancer. Aberrant activation of this pathway is associated with cell proliferation, invasive behaviors, and cell resistance, suggesting its potential value as a therapeutic target in treatment of CRC. Several agents have been developed for targeting of this pathway (e.g, natural agents: curcumin, 3,3-diindolylmethane, phytoestrogen; Synthetic/small Wnt inhibitors: Rofecoxib; PRI-724, CWP232291; and monoclonal antibody against frizzled receptors, Vanituctumab). This review summarizes the current knowledge about the therapeutic potential of targeting Wnt pathway with particular emphasis on preclinical/clinical studies in treatment of colorectal cancer. J. Cell. Biochem. 118: 1979-1983, 2017. (c) 2017 Wiley Periodicals, Inc.
引用
收藏
页码：1979 / 1983
页数：5
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