Induction of cytochrome P450 3A1 expression by diallyl disulfide: Protective effects against cyclophosphamide-induced embryo-fetal developmental toxicity

被引:10
|
作者
Kim, Sung-Hwan [1 ,2 ]
Lee, In-Chul [1 ]
Baek, Hyung-Seon [1 ]
Moon, Changjong [1 ]
Kim, Sung-Ho [1 ]
Yoo, Jin Cheol [3 ]
Shin, In-Sik [1 ,4 ]
Kim, Jong-Choon [1 ]
机构
[1] Chonnam Natl Univ, Coll Vet Med, Kwangju 500757, South Korea
[2] Korea Inst Toxicol, Jeonbuk Dept Nonhuman Primate, Jeonbuk 580185, South Korea
[3] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea
[4] Korea Res Inst Biosci & Biotechnol, Nat Med Res Ctr, Chungbuk 363883, South Korea
基金
新加坡国家研究基金会;
关键词
Cyclophosphamide; Diallyl disulfide; Developmental toxicity; Cytochrome P450 3A1; Oxidative stress; ALPHA-LIPOIC ACID; ORGANOSULFUR COMPOUNDS; INDUCED TERATOGENESIS; HEMORRHAGIC CYSTITIS; DRUG-METABOLISM; GARLIC OIL; RAT-LIVER; ENZYMES; GLUTATHIONE; EXTRACT;
D O I
10.1016/j.fct.2014.04.024
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
The protective effects of diallyl disulfide (DADS) on cyclophosphamide (CP)-induced developmental toxicity and the possible mechanisms involved in this protection were investigated in rats. In order to study the mechanisms involved in the protection, we examined the effects of DADS on the expression of cytochrome P450 (CYP) 3A1 in the maternal liver and placenta and oxidative stress in the maternal hepatic tissues caused by CP. CP caused severe embryo-fetal developmental toxicity and hepatic oxidative stress. In contrast, DADS treatment significantly attenuated CP-induced developmental toxicity and oxidative damage in the maternal liver. DADS also significantly increased expression of CYP3A1 in the maternal liver and placenta. These results indicate that the protective effects of DADS against CP-induced developmental toxicity may be due to its ability to promote detoxification of CP, primarily by inducing CYP3A1 expression in the maternal liver and placenta, and its potent antioxidant effects. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:312 / 319
页数:8
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