LOW-DOSE INVOLVED-FIELD RADIOTHERAPY AS ALTERNATIVE TREATMENT OF NODULAR LYMPHOCYTE PREDOMINANCE HODGKIN'S LYMPHOMA

被引：14
|
作者：
Haas, Rick L. M. [1 ]
Girinsky, Theo [4 ]
Aleman, Berthe M. P. [1 ]
Henry-Amar, Michel [5 ]
de Boer, Jan-Paul [2 ]
de Jong, Daphne [3 ]
机构：
[1] Netherlands Canc Inst, Dept Radiotherapy, NL-1066 CX Amsterdam, Netherlands
[2] Netherlands Canc Inst, Dept Med Oncol, NL-1066 CX Amsterdam, Netherlands
[3] Netherlands Canc Inst, Dept Pathol, NL-1066 CX Amsterdam, Netherlands
[4] Inst Gustave Roussy, Dept Radiotherapy, Paris, France
[5] Ctr Francois Baclesse, Clin Res Unit, F-14021 Caen, France
来源：
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2009年 / 74卷 / 04期
关键词：
GERMINAL CENTER; PHASE-2; TRIAL; DISEASE; RADIATION; RITUXIMAB;
D O I：
10.1016/j.ijrobp.2008.09.049
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: Nodular lymphocyte predominance Hodgkin's lymphoma is a very rare disease, characterized by an indolent clinical course, with sometimes very late relapses occurring in a minority of all patients. Considerable discussion is ongoing on the treatment of primary and relapsed disease. Patients and Methods: A group of 9 patients were irradiated to a dose of 4 Gy on involved areas only. Results: After a median follow-up of 37 months (range, 6-66), the overall response rate was 89%. Six patients had complete remission (67%), two had partial remission (22%), and one had stable disease (11%). Of 8 patients, 5 developed local relapse 9-57 months after radiotherapy. No toxicity was noted. Conclusion: In nodular lymphocyte predominance Hodgkin's lymphoma, low-dose radiotherapy provided excellent response rates and lasting remissions without significant toxicity. (C) 2009 Elsevier Inc.
引用
收藏
页码：1199 / 1202
页数：4
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