HIF-1 promotes the expression of its α-subunit via an epigenetically regulated transactivation loop

被引：10

作者：

Asby, D. J. ^{[1
]}

Cuda, F. ^{[1
]}

Hoakwie, F. ^{[1
]}

Miranda, E. ^{[1
]}

Tavassoli, A. ^{[1
,2
]}

机构：

[1] Univ Southampton, Southampton SO17 1BJ, Hants, England

[2] Univ Southampton, Fac Med, Southampton SO16 6YD, Hants, England

来源：

MOLECULAR BIOSYSTEMS | 2014年 / 10卷 / 10期

关键词：

HYPOXIA-INDUCIBLE FACTOR; SMALL-MOLECULE INHIBITORS; CYCLIC PEPTIDE INHIBITOR; FACTOR-I; GENE-TRANSCRIPTION; CANCER-CELLS; TUMOR-GROWTH; HIF-1-ALPHA; BINDING; INDUCTION;

D O I：

10.1039/c4mb00351a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypoxia inducible factor-1 (HIF-1) directs the cellular response to low oxygen and plays a key role in tumour survival and growth. Here we use an inhibitor of the HIF-1 alpha/HIF-1 beta protein-protein interaction to show the presence of an epigenetically controlled transactivation loop whereby the HIF-1 transcription factor promotes the expression of its own alpha-subunit in hypoxic cancer cells.

引用

页码：2505 / 2508

页数：4

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