Relationship between LINC00341 expression and cancer prognosis

被引:13
|
作者
Liao, Meijian [1 ,2 ]
Li, Bing [1 ,2 ]
Zhang, Shikuan [2 ]
Liu, Qing [1 ,2 ]
Liao, Weijie [1 ,2 ]
Xie, Weidong [2 ,3 ]
Zhang, Yaou [2 ,3 ]
机构
[1] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
[2] Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Key Lab Hlth Sci & Technol, Shenzhen 518055, Peoples R China
[3] Tsinghua Univ, Open FIESTA Ctr, Shenzhen 518055, Peoples R China
基金
中国国家自然科学基金;
关键词
LncRNA; LINC00341; metastasis; meta-analysis; prognostication; LONG NONCODING RNA; BREAST-CANCER; GENOMIC ALTERATIONS; COLORECTAL-CANCER; PROSTATE-CANCER; METASTASIS; SURVIVAL; IDENTIFICATION; BIOMARKERS; SIGNATURE;
D O I
10.18632/oncotarget.14843
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
LINC00341 is a novel long intergenic non-protein coding RNA with unknown functions. In our report, we investigated LINC00341 expression and its prognostic value in cancer patients. DNA over-methylation triggered low expression of LINC00341 and that was associated with poor prognosis in cancers. A meta-analysis further confirmed that high expression of LINC00341 was associated with a better prognosis in cancer patients. Both gene set enrichment analysis and meta-analysis showed that LINC00341 inhibited cancer metastasis. Finally, a large-scale multicentre analysis supported a prognostic value of LINC00341 in cancers.
引用
收藏
页码:15283 / 15293
页数:11
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