Sunitinib loaded chitosan nanoparticles formulation and its evaluation

被引：63

作者：

Joseph, Jayapal John ^{[1
]}

Sangeetha, D. ^{[1
]}

Gomathi, Thandapani ^{[2
]}

机构：

[1] VIT Univ, Sch Adv Sci, Environm & Analyt Chem Div, Vellore 632014, Tamil Nadu, India

[2] DKM Coll Women, Dept Chem, Vellore 632001, Tamil Nadu, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2016年 / 82卷

关键词：

Sunitinib; Chitosan nanoparticles; Ionic crosslinking; GROWTH-FACTOR; DELIVERY; RELEASE; SU11248; CARRIER; SURFACE; SAFETY;

D O I：

10.1016/j.ijbiomac.2015.10.079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nano-polymeric pharmaceutical excipient such as chitosan nanoparticles (CS-NPs) were synthesized for formulating the anticancer drug Sunitinib (STB). The formulation was done through the simple ionic cross linking method. The prepared formulation was characterized by DLS, SEM, FT-IR and XRD. The DLS study reveals that the Sunitinib loaded chitosan nanoparticles (SNB-CS-NPs) were in the size range of <200 nm. Encapsulation of Sunitinib and validation for the formulation was done using UV spectrophotometry. In vitro drug release and its cytotoxic studies were performed for STB-CS-NPs. This study implies the novel drug delivery system for Sunitinib for the effective sustained delivery. (C) 2015 Elsevier B.V. All rights reserved.

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页码：952 / 958

页数：7

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