Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota

被引:52
|
作者
Loke, Yean Leng [1 ]
Chew, Ming Tsuey [1 ]
Ngeow, Yun Fong [2 ,3 ]
Lim, Wendy Wan Dee [4 ]
Peh, Suat Cheng [5 ,6 ]
机构
[1] Sunway Univ, Ctr Biomed Phys, Sch Healthcare & Med Sci, Petaling Jaya, Malaysia
[2] Univ Tunku Abdul Rahman, Fac Med & Hlth Sci, Kajang, Malaysia
[3] Univ Tunku Abdul Rahman, Ctr Res Communicable Dis, Kajang, Malaysia
[4] Sunway Med Ctr, Dept Gastroenterol, Petaling Jaya, Malaysia
[5] Sunway Univ, Ageing Hlth & Well Being Res Ctr, Petaling Jaya, Malaysia
[6] Sunway Univ, Sch Healthcare & Med Sci, Dept Med Sci, Petaling Jaya, Malaysia
关键词
colorectal cancer; colon carcinogenesis; diet; gut microbiota; protein; fat; carbohydrate; bacteria interaction; COLORECTAL-CANCER RISK; TRIMETHYLAMINE-N-OXIDE; INFLAMMATORY-BOWEL-DISEASE; POLYCYCLIC AROMATIC-HYDROCARBONS; ABERRANT CRYPT FOCI; FACTOR-KAPPA-B; FUSOBACTERIUM-NUCLEATUM; RED MEAT; NITROSO COMPOUNDS; GLYCEMIC INDEX;
D O I
10.3389/fcimb.2020.603086
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Colorectal cancer (CRC) incidence increases yearly, and is three to four times higher in developed countries compared to developing countries. The well-known risk factors have been attributed to low physical activity, overweight, obesity, dietary consumption including excessive consumption of red processed meats, alcohol, and low dietary fiber content. There is growing evidence of the interplay between diet and gut microbiota in CRC carcinogenesis. Although there appears to be a direct causal role for gut microbes in the development of CRC in some animal models, the link between diet, gut microbes, and colonic carcinogenesis has been established largely as an association rather than as a cause-and-effect relationship. This is especially true for human studies. As essential dietary factors influence CRC risk, the role of proteins, carbohydrates, fat, and their end products are considered as part of the interplay between diet and gut microbiota. The underlying molecular mechanisms of colon carcinogenesis mediated by gut microbiota are also discussed. Human biological responses such as inflammation, oxidative stress, deoxyribonucleic acid (DNA) damage can all influence dysbiosis and consequently CRC carcinogenesis. Dysbiosis could add to CRC risk by shifting the effect of dietary components toward promoting a colonic neoplasm together with interacting with gut microbiota. It follows that dietary intervention and gut microbiota modulation may play a vital role in reducing CRC risk.
引用
下载
收藏
页数:26
相关论文
共 50 条
  • [1] Interplay between the gut microbiota, immunity and colon cancer
    Lange, E.
    Adamczyk, A.
    Westendorf, A. M.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 142 - 142
  • [2] Interplay between bile acids and the gut microbiota promotes intestinal carcinogenesis
    Wang, Sinan
    Dong, Wenxiao
    Liu, Li
    Xu, Mengque
    Wang, Yu
    Liu, Tianyu
    Zhang, Yujie
    Wang, Bangmao
    Cao, Hailong
    MOLECULAR CARCINOGENESIS, 2019, 58 (07) : 1155 - 1167
  • [3] Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer
    Bultman, Scott J.
    MOLECULAR NUTRITION & FOOD RESEARCH, 2017, 61 (01)
  • [4] The interplay between PCOS pathology and diet on gut microbiota in a mouse model
    Rodriguez Paris, Valentina
    Wong, Xin Yi Denise
    Solon-Biet, Samantha M.
    Edwards, Melissa C.
    Aflatounian, Ali
    Gilchrist, Robert B.
    Simpson, Stephen J.
    Handelsman, David J.
    Kaakoush, Nadeem O.
    Walters, Kirsty A.
    GUT MICROBES, 2022, 14 (01)
  • [5] Toxigenic gut bacteria, diet and colon carcinogenesis
    Keenan, Jacqueline, I
    Frizelle, Frank A.
    JOURNAL OF THE ROYAL SOCIETY OF NEW ZEALAND, 2020, 50 (03) : 418 - 433
  • [6] The interplay between sleep and gut microbiota
    Han, Mengqi
    Yuan, Shiying
    Zhang, Jiancheng
    BRAIN RESEARCH BULLETIN, 2022, 180 : 131 - 146
  • [7] Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis
    Seyedeh Zahra Bakhti
    Saeid Latifi-Navid
    BMC Microbiology, 21
  • [8] Interplay between Anthocyanins and Gut Microbiota
    Faria, Ana
    Fernandes, Iva
    Norberto, Sonia
    Mateus, Nuno
    Calhau, Conceicao
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2014, 62 (29) : 6898 - 6902
  • [9] Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis
    Bakhti, Seyedeh Zahra
    Latifi-Navid, Saeid
    BMC MICROBIOLOGY, 2021, 21 (01)
  • [10] The mutual interplay of gut microbiota, diet and human disease
    Illiano, Placido
    Brambilla, Roberta
    Parolini, Cinzia
    FEBS JOURNAL, 2020, 287 (05) : 833 - 855