Radiosynthesis of 3-[18F]fluoropropyl and 4-[18F]fluorobenzyl triarylphosphonium ions

被引：57
|
作者：
Ravert, HT [1 ]
Madar, I [1 ]
Dannals, RF [1 ]
机构：
[1] Johns Hopkins Med Inst, Dept Radiol, Div Nucl Med, Baltimore, MD 21287 USA
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2004年 / 47卷 / 08期
关键词：
phosphonium; fluorine-18; positron emission tomography;
D O I：
10.1002/jlcr.835
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
3-[F-18]Fluoropropyl-, 4-[F-18]fluorobenzyl-triphenylphosphonium and 4-[F-18]fluorobenzyltris-4-dimethylaminophenylphosphonium cations were synthesized in multistep reactions from no carrier added (nca) [F-18]fluoride. The time for synthesis, purification, and formulation was 56, 82, and 79min with an average radiochemical yield of 12, 6 and 15%, respectively (not corrected for decay). The average specific radioactivity for the three radiolabeled compounds was 14.9GBq/mumole (403mCi/ mumole) at end of synthesis (EOS). Copyright (C) 2004 John Wiley Sons, Ltd.
引用
收藏
页码：469 / 476
页数：8
相关论文
共 50 条
  • [1] Radiosynthesis and analysis of (S)-4-(3-[18F]fluoropropyl)-Lglutamic acid
    Brown, Gavin
    Solovyev, Dmitry
    Lewis, David
    [J]. NUCLEAR MEDICINE AND BIOLOGY, 2023, 126 : S73 - S74
  • [2] Radiosynthesis and Analysis of (S)-4-(3-[18F]Fluoropropyl)-L-Glutamic Acid
    Brown, Gavin
    Soloviev, Dmitry
    Lewis, David Y. Y.
    [J]. MOLECULAR IMAGING AND BIOLOGY, 2023, 25 (03) : 586 - 595
  • [3] Radiosynthesis and Analysis of (S)-4-(3-[18F]Fluoropropyl)-L-Glutamic Acid
    Gavin Brown
    Dmitry Soloviev
    David Y. Lewis
    [J]. Molecular Imaging and Biology, 2023, 25 : 586 - 595
  • [4] Utility of azetidinium methanesulfonates for radiosynthesis of 3-[18F]fluoropropyl amines
    Kiesewetter, DO
    Eckelman, WC
    [J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2004, 47 (13): : 953 - 969
  • [5] Synthesis and basic evaluation of 7α-(3-[18F]fluoropropyl)-testosterone and 7α-(3-[18F]fluoropropyl)-dihydrotestosterone
    Okamoto, Mayumi
    Naka, Kyosuke
    Ishiwata, Kiichi
    Shimizu, Isao
    Toyohara, Jun
    [J]. ANNALS OF NUCLEAR MEDICINE, 2017, 31 (01) : 53 - 62
  • [6] Synthesis and basic evaluation of 7α-(3-[18F]fluoropropyl)-testosterone and 7α-(3-[18F]fluoropropyl)-dihydrotestosterone
    Mayumi Okamoto
    Kyosuke Naka
    Kiichi Ishiwata
    Isao Shimizu
    Jun Toyohara
    [J]. Annals of Nuclear Medicine, 2017, 31 : 53 - 62
  • [7] Radiosynthesis of 3-(2′-[18F]fluoro)-flumazenil ([18F]FFMZ)
    Wadsak, W
    Mitterhauser, M
    Mien, LK
    Tögel, S
    Keppler, B
    Dudczak, R
    Kletter, K
    [J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2003, 46 (13): : 1229 - 1240
  • [8] Radiosynthesis of 4-[18F] Fluoronapthol Derivative
    [J]. J Labelled Compd Radiopharm, (584):
  • [9] Automation of 4-[18F]fluorogabapentin radiosynthesis
    Zhou, Yu-Peng
    Brugarolas, Pedro
    [J]. NUCLEAR MEDICINE AND BIOLOGY, 2021, 96-97 : S66 - S66
  • [10] Radiosynthesis of [18F]fluoromethyl tosylate for [18F]fluoromethylation
    Friederike, Beyerlein
    Markus, Piel
    Tobias, Ross L.
    Frank, Roech
    [J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2011, 54 : S483 - S483
12345