Use of Dexamethasone to Prevent Extubation Failure in Pediatric Intensive Care Unit: A Randomized Controlled Clinical Trial

被引：5

作者：

de Carvalho, Haroldo Teofilo ^{[1
]}

Fioretto, Jose Roberto ^{[1
]}

Bonatto, Rossano Cesar ^{[1
]}

Ribeiro, Cristiane Franco ^{[1
]}

Martin, Joelma Goncalves ^{[1
]}

Carpi, Mario Ferreira ^{[1
]}

机构：

[1] Sao Paulo State Univ, UNESP, Dept Pediat, Botucatu Sch Med, Botucatu, SP, Brazil

来源：

JOURNAL OF PEDIATRIC INTENSIVE CARE | 2022年 / 11卷 / 01期

关键词：

children; extubation failure; dexamethasone; POSTEXTUBATION AIRWAY-OBSTRUCTION; SIMULTANEOUS CONFIDENCE-INTERVALS; DOUBLE-BLIND; RISK-FACTORS; VENTILATION; REINTUBATION; EPINEPHRINE; EFFICACY; CHILDREN; STRIDOR;

D O I：

10.1055/s-0040-1719044

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Extubation failure is a common event in intensive care units. Corticosteroids are effective in preventing failure in adults, but no consensus has been reached on this matter in pediatrics. We assessed the efficacy of intravenous dexamethasone in mechanically ventilated children and adolescents for more than 48hours, with at least one risk factor for failure. Extubations were scheduled 24hours in advance when possible, and patients were randomly assigned into two groups: one group received a loading dose followed by up to four doses of dexamethasone, and the other group received no corticosteroids. Need for reintubation and length of stay in the pediatric intensive care unit were similar in both groups, and frequency of reintubation was 12.9%.

引用

页码：41 / 47

页数：7

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