Magnetic resonance elastography in the assessment of hepatic fibrosis: a study comparing transient elastography and histological data in the same patients

被引:16
|
作者
Toguchi, Masafumi [1 ]
Tsurusaki, Masakatsu [1 ]
Yada, Norihisa [2 ]
Sofue, Keitaro [3 ]
Hyodo, Tomoko [1 ]
Onoda, Minori [4 ,5 ]
Numoto, Isao [1 ]
Matsuki, Mitsuru [1 ]
Imaoka, Izumi [1 ]
Kudo, Masatoshi [2 ]
Murakami, Takamichi [1 ]
机构
[1] Kindai Univ, Fac Med, Dept Radiol, 377-2 Ohno Higashi, Osaka 5898511, Japan
[2] Kindai Univ, Fac Med, Dept Gastroenterol & Hepatol, Osaka, Japan
[3] Kobe Univ, Grad Sch Med, Dept Radiol, Chuo Ku, 7-5-2 Kusunoki Cho, Kobe, Hyogo 6500017, Japan
[4] Kindai Univ, Dept Radiol Technol, 377-2 Ohno Higashi, Osaka 5898511, Japan
[5] Kanazawa Univ, Grad Sch Med Sci, Devis Hlth Sci, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 9200942, Japan
基金
日本学术振兴会;
关键词
elastography; Transient elastography; Liver fibrosis; Fibrosis assessment; Chronic liver disease; MR ELASTOGRAPHY; LIVER FIBROSIS; STIFFNESS; DISEASES;
D O I
10.1007/s00261-017-1045-3
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To evaluate the quantitative measurement of liver stiffness (LS), compare the diagnostic performance of magnetic resonance elastography (MRE) and ultrasound-based transient elastography (TE), and evaluate two different MRE-based LS measurement methods. Methods: Between October 2013 and January 2015, 116 consecutive patients with chronic liver disease underwent MRE to measure LS (kilopascals; kPa). Of the 116 patients, 51 patients underwent both TE and liver biopsy, and the interval between the liver biopsy and both the MRE and TE was less than 90 days. MRE-derived LS values were measured on the anterior segment of the right lobe (single small round regions of interest per slice; srROIs) and whole right lobe of the liver (free hand region of interest; fhROI), and these values were correlated with pathological fibrosis grades and diagnostic performance. Results: Pathological fibrosis stage was significantly correlated with srROIs (r = 0.87, p < 0.001), fhROI (r = 0.80, p < 0.001), and TE (r = 0.73, p < 0.001). For detection of significant fibrosis (>= F2), advanced fibrosis (>= F3), and cirrhosis, the area under the curve (AUC) associated with the srROIs was largest, and there was a significant difference between srROIs and TE (0.93 vs. 0.82, p = 0.006), srROIs and fhROI (0.93 vs. 0.89, p = 0.04) for detection of >= F2. For advanced fibrosis and cirrhosis detection, AUCs were not significant (0.92-0.96). Conclusions: MRE and TE detected liver fibrosis with comparable accuracy. In particular, the srROIs method was effective for detecting of significant fibrosis.
引用
收藏
页码:1659 / 1666
页数:8
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