Gut hormone profiles in preterm and term infants during the first 2 months of life

被引：17

作者：

Kawamata, Ryou ^{[1
]}

Suzuki, Yume ^{[1
]}

Yada, Yukari ^{[1
]}

Koike, Yasunori ^{[1
]}

Kono, Yumi ^{[1
]}

Yada, Toshihiko ^{[2
]}

Takahashi, Naoto ^{[3
]}

机构：

[1] Jichi Med Univ, Sch Med, Dept Pediat, Shimotsuke, Tochigi 3290498, Japan

[2] Jichi Med Univ, Sch Med, Dept Integrat Physiol, Shimotsuke, Tochigi 3290498, Japan

[3] Univ Tokyo, Dept Pediat, Tokyo, Japan

来源：

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2014年 / 27卷 / 7-8期

关键词：

glucagon-like peptide-1; glucose-dependent insulinotropic polypeptide; leptin; neonates; pancreatic polypeptide; peptide YY; premature infants; PEPTIDE YY; PANCREATIC-POLYPEPTIDE; CORD BLOOD; LEPTIN; EXPRESSION; INTRAUTERINE; GHRELIN; GROWTH; PYY;

D O I：

10.1515/jpem-2013-0385

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: To investigate changes of gut hormones in term and preterm infants in the first 2 months after birth, as the role and relationships of gut hormones in premature infants has not been well elucidated. Methods: In 29 preterm and five term infants, fasting serum concentrations of leptin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), pancreatic polypeptide, insulin, amylin, and ghrelin were measured using a bead array system. Results: Serum leptin concentration soon after birth showed a positive correlation with gestational week in all infants (r=0.623, p<0.01). Serum leptin level rapidly decreased in all infants. In preterm infants, serum GLP-1 levels at birth showed negative correlations with gestational week (r=-0.447, p=0.02). Serum GIP, GLP-1, and PYY levels increased after birth and were persistently high until 10 weeks of life. Conclusion: Serum concentrations of different gut hormones changed postnatally in their specific ways in preterm infants.

引用

页码：717 / 723

页数：7

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