Clinical characterization of COVID-19 breakthrough infections, Philippines

被引：4
|
作者：
Velasco, John Mark [1 ,3 ]
Vila, Vicente [2 ]
Diones, Paula Corazon [1 ]
Valderama, Maria Theresa [1 ]
Mendez, Cecille [2 ]
Turao-Agoncillo, Ma Melissa Monica [2 ]
Chinnawirotpisan, Piyawan [1 ]
Manasatienkij, Wudtichai [1 ]
Joonlasak, Khajohn [1 ]
Klungthong, Chonticha [1 ]
Jones, Anthony [1 ]
Fernandez, Stefan [1 ]
Navarro, Fatima Claire [2 ]
机构：
[1] US Army Med Directorate, Armed Forces Res Inst Med Sci, Bangkok, Thailand
[2] Armed Forces Philippines Hlth Serv Command, V Luna Med Ctr, Quezon City, Philippines
[3] Univ Philippines Manila, Manila, Philippines
来源：
JOURNAL OF CLINICAL VIROLOGY | 2022年 / 150卷
关键词：
SARS-CoV-2; Breakthrough infections; Philippines;
D O I：
10.1016/j.jcv.2022.105157
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We clinically characterized PCR detected breakthrough infections among partially/fully vaccinated cases with majority given an inactivated vaccine, CoronaVac. From 1 March to 15 July 2021, we detected 182 SARS-CoV-2 infections among vaccinated cases with 129 classified as breakthrough infections. Majority were male, 30-39 y. o., and were asymptomatic or mildly symptomatic with few severe cases. Alpha, Beta and Delta VOCs were detected from sequenced breakthrough infections. Healthcare workers had significantly lower Ct values(higher viral loads) versus non-HCWs. Our results underscore the importance of regular PCR screening for HCWs due to the risk of SARS-CoV-2 transmission from asymptomatic breakthrough infections and provide evidence supporting administration of a booster dose especially to HCWs
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页数：4
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