Biosynthesis and roles of phospholipids in mitochondrial fusion, division and mitophagy

被引：41

作者：

Zhang, Qiang ^{[1
]}

Tamura, Yasushi ^{[2
]}

Roy, Madhuparna ^{[1
]}

Adachi, Yoshihiro ^{[1
]}

Iijima, Miho ^{[1
]}

Sesaki, Hiromi ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD 21218 USA

[2] Nagoya Univ, Inst Adv Res, Chikusa Ku, Nagoya, Aichi 4648601, Japan

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2014年 / 71卷 / 19期

关键词：

Dynamin-related GTPase; Mitochondrial fission; Mitochondrial fusion; Mitophagy; Apoptosis; Drp1; Mitofusin; Opa1; DYNAMIN-RELATED GTPASE; PHOSPHATIDYLETHANOLAMINE METHYLATION PATHWAY; INTERMEMBRANE SPACE PROTEIN; INNER-MEMBRANE-FUSION; WD REPEAT PROTEIN; PHOSPHATIDYLSERINE DECARBOXYLASE; SACCHAROMYCES-CEREVISIAE; ALTERNATIVE TOPOGENESIS; INTRAMITOCHONDRIAL TRANSPORT; CARDIOLIPIN BIOSYNTHESIS;

D O I：

10.1007/s00018-014-1648-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria move, fuse and divide in cells. The dynamic behavior of mitochondria is central to the control of their structure and function. Three conserved mitochondrial dynamin-related GTPases (i.e., mitofusin, Opa1 and Drp1 in mammals and Fzo1, Mgm1 and Dnm1 in yeast) mediate mitochondrial fusion and division. In addition to dynamins, recent studies demonstrated that phospholipids in mitochondria also play key roles in mitochondrial dynamics by interacting with dynamin GTPases and by directly changing the biophysical properties of the mitochondrial membranes. Changes in phospholipid composition also promote mitophagy, which is a selective mitochondrial degradation process that is mechanistically coupled to mitochondrial division. In this review, we will discuss the biogenesis and function of mitochondrial phospholipids.

引用

页码：3767 / 3778

页数：12

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