Hydrazones and new oximes of 4-aminobicyclo[2.2.2]octanones and their antiprotozoal activities

被引：2

作者：

Weis, Robert ^{[1
]}

Kaiser, Marcel

Brun, Reto

Saf, Robert

Seebacher, Werner

机构：

[1] Karl Franzens Univ Graz, Inst Pharmaceut Sci, Graz, Austria

[2] Swiss Trop Inst, CH-4002 Basel, Switzerland

[3] Erzherzog Johann Univ, Inst Chem Technol Organ Mat, Graz, Austria

来源：

MONATSHEFTE FUR CHEMIE | 2006年 / 137卷 / 10期

关键词：

antiprotozoal activity; imines; isomers; ketones; NMR spectroscopy;

D O I：

10.1007/s00706-006-0535-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

4-Aminobicyclo[2.2.2]octan-2-ones and -ols showed activity against the causative organisms of East African sleeping sickness and Malaria tropica. Several imino derivatives of the ketones were more active. Now hydrazono analogues and 3-hydroximino derivatives of the ketones and alcohols were synthesized. The structures of the obtained isomers were elucidated by NMR spectroscopy. A single phenylhydrazone exhibited quite good antitrypanosomal activity in the range of already known imino analogues.

引用

页码：1365 / 1374

页数：10

共 24 条

[1] Hydrazones and new Oximes of 4-Aminobicyclo[2.2.2]octanones and their Antiprotozoal Activities
Robert Weis
Marcel Kaiser
Reto Brun
Robert Saf
Werner Seebacher
Monatshefte für Chemie / Chemical Monthly, 2006, 137 : 1365 - 1374
[2] 4-aminobicyclo[2.2.2]octanone derivatives with antiprotozoal activities
Weis, R
Brun, R
Saf, R
Seebacher, W
MONATSHEFTE FUR CHEMIE, 2003, 134 (07): : 1019 - 1026
[3] 4-Aminobicyclo[2.2.2]octanone Derivatives with Antiprotozoal Activities
Robert Weis
Reto Brun
Robert Saf
Werner Seebacher
Monatshefte für Chemie / Chemical Monthly, 2003, 134 : 1019 - 1026
[4] Investigations on the formation of 4-aminobicyclo[2.2.2]octanones
Seebacher, W
Kröpfl, D
Belaj, F
Saf, R
Hüfner, A
Weis, R
MOLECULES, 2005, 10 (3-5) : 521 - 533
[5] New derivatives of 4-aminobicyclo[2.2.2]octanones and -ols as potential antiprotozoals
Seebacher, W
Brun, R
Saf, R
Kröpfl, D
Weis, R
MONATSHEFTE FUR CHEMIE, 2004, 135 (03): : 313 - 322
[6] New Derivatives of 4-Aminobicyclo [2.2.2]octanones and -ols as Potential Antiprotozoals
Werner Seebacher
Reto Brun
Robert Saf
Dietmar Kröpfl
Robert Weis
Monatshefte für Chemie / Chemical Monthly, 2004, 135 : 313 - 322
[7] Synthesis of new esters and oximes with 4-aminobicyclo [2.2.2] octane structure and evaluation of their antitrypanosomal and antiplasmodial activities
Seebacher, W.
Schlapper, C.
Brun, R.
Kaiser, M.
Saf, R.
Weis, R.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2006, 41 (08) : 970 - 977
[8] 4-Aminobicyclo[2.2.2]octan-2-yl 4-aminobutanoates with antiprotozoal activity
Weis, Robert
Seebacher, Werner
Brun, Reto
Kaiser, Marcel
Saf, Robert
Faist, Johanna
MONATSHEFTE FUR CHEMIE, 2014, 145 (02): : 311 - 317
[9] 4-Aminobicyclo[2.2.2]octan-2-yl 4-aminobutanoates with antiprotozoal activity
Robert Weis
Werner Seebacher
Reto Brun
Marcel Kaiser
Robert Saf
Johanna Faist
Monatshefte für Chemie - Chemical Monthly, 2014, 145 : 311 - 317
[10] 4-aminobicyclo[2.2.2]octanone derivatives with antiplasmodial and antitrypanosomal activities
Seebacher, W
Brun, R
Saf, R
Weis, R
MONATSHEFTE FUR CHEMIE, 2003, 134 (10): : 1411 - 1420

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