The Application of Neural Stem/ Progenitor Cells for Regenerative Therapy of Spinal Cord Injury

被引：11
|
作者：
Yu, Chao [1 ,2 ]
Xia, Kaishun [1 ,2 ]
Gong, Zhe [1 ,2 ]
Ying, Liwei [1 ,2 ]
Shu, Jiawei [1 ,2 ]
Zhang, Feng [1 ,2 ]
Chen, Qixin [1 ,2 ]
Li, Fangcai [1 ,2 ]
Liang, Chengzhen [1 ,2 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Orthoped, 88 Jie Fang Rd, Hangzhou 310009, Zhejiang, Peoples R China
[2] Zhejiang Univ, Orthoped Res Inst, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China
来源：
CURRENT STEM CELL RESEARCH & THERAPY | 2019年 / 14卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Spinal cord injury; neural induction; neural stem cell; pluripotent stem cell; patient; macrophages; TRANSPLANTATION THERAPY; AXONAL REGENERATION; HUMAN ES; DIFFERENTIATION; GENERATION; INDUCTION; NEURONS; SPECIFICATION; REMYELINATION; FIBROBLASTS;
D O I：
10.2174/1574888X14666190329095638
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Spinal cord injury (SCI) is a devastating event, and there are still no effective therapies currently available. Neural stem cells (NSCs) have gained increasing attention as promising regenerative therapy of SCI. NSCs based therapies of various neural diseases in animal models and clinical trials have been widely investigated. In this review we aim to summarize the development and recent progress in the application of NSCs in cell transplantation therapy for SCI. After brief introduction on sequential genetic steps regulating spinal cord development in vivo, we describe current experimental approaches for neural induction of NSCs in vitro. In particular, we focus on NSCs induced from pluripotent stem cells (PSCs). Finally, we highlight recent progress on the NSCs, which show great promise in the application to regeneration therapy for SCI.
引用
收藏
页码：495 / 503
页数：9
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