On-line monitoring of process HPLC by sensors

被引：7
|
作者：
Wessa, T [1 ]
Küppers, S
Mann, G
Rapp, M
Reibel, J
机构：
[1] Schering AG, Chem Dev, D-13342 Berlin, Germany
[2] Forschungszentrum Karlsruhe, IFIA B341, D-76021 Karlsruhe, Germany
[3] Burkert GmbH&CoKg, D-01900 Grosshansdorf, Germany
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2000年 / 4卷 / 02期
关键词：
D O I：
10.1021/op990080v
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
On-line process control with a SAW (surface acoustic wave) sensor-based gas-sensor microsystem (SAGAS PC = surface acoustic wave based aroma and gas analyzing system) for industrial applications is presented. The monitoring of the gradient former of a preparative HPLC system is a useful tool for the on-line process control of pilot plant production. All applications deal with the detection and subsequent qualification as well as quantitation of volatile organic compounds (VOCs), for example, organic solvents or even water, by investigating their vapor with the SAGAS PC-system. To demonstrate the suitability of the system for the above-mentioned purpose different examples of typical binary solvent mixtures for normal phase (NP) HPLC have been chosen. The accuracy, precision, and robustness of the applied method are determined, and the results meet the specification requirements. Furthermore, online measurements in a pilot plant environment are presented.
引用
收藏
页码：102 / 106
页数：5
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