Comparison of the effects of Mg-6Zn and Ti-3Al-2.5V alloys on TGF-β/TNF-α/VEGF/b-FGF in the healing of the intestinal tract in vivo

被引：18

作者：

Yan, Jun ^{[1
,2
]}

Chen, Yigang ^{[1
,2
]}

Yuan, Qingling ^{[3
]}

Wang, Xiaohu ^{[1
]}

Yu, Song ^{[1
]}

Qiu, Wencai ^{[1
]}

Wang, Zhigang ^{[1
,2
]}

Ai, Kaixing ^{[1
,2
]}

Zhang, Xiaonong ^{[4
,5
]}

Zhang, Shaoxiang ^{[5
]}

Zhao, Changli ^{[4
]}

Zheng, Qi ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Gen Surg, Shanghai 200233, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China

[3] Zhengzhou Univ, Affiliated Hosp 1, Dept Thyroid Surg, Zhengzhou 450052, Henan, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China

[5] Suzhou Origin Med Technol Co Ltd, Suzhou 215513, Jiangsu, Peoples R China

来源：

BIOMEDICAL MATERIALS | 2014年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Mg-Zn alloy; degradable; in vivo; healing; angiogenesis; FIBROBLAST-GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; MAGNESIUM ALLOYS; VITRO DEGRADATION; ABSORBABLE METAL; CORROSION; BEHAVIOR; BIOCOMPATIBILITY; EXPRESSION; ZINC;

D O I：

10.1088/1748-6041/9/2/025011

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

To evaluate the different effects of Mg-6Zn alloy and Ti-3Al-2.5V alloy implants in intestinal tract healing, we compared these two different alloys with respect to their effect on a rat's intestinal tract, using serum magnesium, radiology, pathology and immunohistochemistry in vivo. It was found using the scanning electron microscope that the Mg-6Zn alloy began to degrade during the first week and that the Ti-3Al-2.5V alloy was non-degradable throughout the process. The Mg-6Zn alloy did not have an impact on serum magnesium. Superior to the Ti-3Al-2.5V alloy, the Mg-6Zn alloy enhanced the expression of transforming growth factor-beta 1 in healing tissue, and promoted the expression of both the vascular endothelial growth factor and the basic fibroblast growth factor, which helped angiogenesis and healing. The Mg-6Zn alloy reduced the expression of the tumor necrosis factor (TNF-alpha) at different stages and decreased inflammatory response, which may have been related to the zinc inhibiting TNF-alpha. In general, the Mg-6Zn alloy performed better than Ti-3Al-2.5V at promoting healing and reducing inflammation. The Mg-6Zn alloy may be a promising candidate for use in the pins of circular staplers for gastrointestinal reconstruction in medicine.

引用

页数：11