Nox4 Inhibition, by GKT 137831, Decreases Obesity-Associated Vascular Dysfunction and Pro-Fibrotic Effects

被引：0
|
作者：
Montezano, Augusto C. [1 ]
Cat, Aurelie Nguyen Dinh [1 ]
Even, Sarah E. [1 ]
Antunes, Tayze [2 ]
Briet, Marie [3 ]
He, Ying [2 ]
Callera, Glaucia E. [2 ]
McCulloch, Jim [1 ]
Carswell, Andrew [1 ]
Jandeleit-Dahm, Karin [4 ]
Cooper, Mark E. [4 ]
Szyndralewiez, Cedric [5 ]
Page, Patrick [5 ]
Touyz, Rhian M. [1 ]
机构：
[1] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland
[2] Univ Ottawa, Kidney Rsch Cntr, Ottawa, ON, Canada
[3] Univ Paris 05, Hop Europeen Georges Pompidou, AP HP, Fac Med, Paris, France
[4] Baker IDI Heart & Diabet Rsch Inst, Melbourne, Vic, Australia
[5] Genkyotex SA, Geneva, Switzerland
来源：
HYPERTENSION | 2013年 / 62卷 / 03期
关键词：
Nox4; Vascular Dysfunction; Obesity;
D O I：
暂无
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
491
引用
收藏
页数：1
相关论文
共 11 条
  • [1] The Nox4 Inhibitor GKT137831 Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation
    Green, David E.
    Murphy, Tamara C.
    Kang, Bum-Yong
    Kleinhenz, Jennifer M.
    Szyndralewiez, Cedric
    Page, Patrick
    Sutliff, Roy L.
    Hart, C. Michael
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2012, 47 (05) : 718 - 726
  • [2] Obesity-associated Inflammation Contributes to Adipose Stromal Cells Pro-fibrotic Phenotype
    Springer, N.
    van den Berg, M.
    Seo, B. R.
    Fischbach, C.
    FASEB JOURNAL, 2015, 29
  • [3] BMP-2 INDUCES A PRO-FIBROTIC PHENOTYPE IN ADULT RENAL PROGENITOR CELLS THROUGH NOX4 ACTIVATION
    Simone, Simona
    Cariello, Marica
    Cosola, Carmela
    Sallustio, Fabio
    Loverre, Antonia
    Schena, Francesco Paolo
    Grandaliano, G.
    Gesualdo, Loreto
    Pertosa, Giovanni
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2012, 27 : 1 - 1
  • [4] Adipocyte-derived Aldosterone And Cortisol Are Nox1/4 Dependent: Implications In Obesity-associated Vascular Dysfunction.
    Even, Sarah E.
    Rios, Francisco J.
    Cat, Aurelie Nguyen Dinh
    Antunes, Tayze T.
    Briet, Marie
    He, Ying
    Callera, Glaucia E.
    Jandeleit-Dahm, Karin
    Cooper, Mark
    Szyndralewiez, Cedric
    Page, Patrick
    Montezano, Augusto C.
    Touyz, Rhian M.
    HYPERTENSION, 2014, 64
  • [5] Differential contribution of Nox1, Nox2 and Nox4 to kidney vascular oxidative stress and endothelial dysfunction in obesity
    Munoz, Mercedes
    Elvira Lopez-Oliva, Maria
    Rodriguez, Claudia
    Pilar Martinez, Maria
    Saenz-Medina, Javier
    Sanchez, Ana
    Climent, Belen
    Benedito, Sara
    Garcia-Sacristan, Albino
    Rivera, Luis
    Hernandez, Medardo
    Prieto, Dolores
    REDOX BIOLOGY, 2020, 28
  • [6] The correlation of IRE1α oxidation with Nox4 activation in aging-associated vascular dysfunction
    Lee, Hwa-Young
    Kim, Hyun-Kyoung
    Hoang, The-Hiep
    Yang, Siyoung
    Kim, Hyung-Ryong
    Chae, Han-Jung
    REDOX BIOLOGY, 2020, 37
  • [7] NOX5 EXPRESSION IN A VASCULAR SMOOTH MUSCLE CELL-SPECIFIC MANNER INDUCES FIBROBLAST PHENOTYPIC SWITCH AND PRO-FIBROTIC EFFECTS
    Montezano, Augusto
    Rios, Francisco
    Blaikie, Zachariel
    Saad, Tomador
    Camargo, Livia
    Palacios-Ramirez, Roberto
    Tarjus, Antoine
    Sagan, Agnieszka
    Beattie, Wendy
    Guzik, Tomasz
    Jaisser, Frederic
    Graham, Delyth
    Touyz, Rhian M.
    JOURNAL OF HYPERTENSION, 2022, 40 (SUPPL) : E37 - E37
  • [8] The correlation of IRE1α oxidation with Nox4 activation in aging-associated vascular dysfunction (vol 37, 101727, 2020)
    Lee, Hwa-Young
    Kim, Hyun-Kyoung
    Hoang, The-Hiep
    Yang, Siyoung
    Kim, Hyung-Ryong
    Chae, Han-Jung
    REDOX BIOLOGY, 2021, 40
  • [9] Protective effects of acarbose against vascular endothelial dysfunction through inhibiting Nox4/NLRP3 inflammasome pathway in diabetic rats
    Li, Xiao-Xue
    Ling, Sun-Kai
    Hu, Ming-Yue
    Ma, Yu
    Li, Yuan
    Huang, Pei-Lin
    FREE RADICAL BIOLOGY AND MEDICINE, 2019, 145 : 175 - 186
  • [10] Improvement of vascular dysfunction by argirein through inhibiting endothelial cell apoptosis associated with ET-1/Nox4 signal pathway in diabetic rats
    Jie Su
    Xing-Rong An
    Qing Li
    Xiao-Xue Li
    Xiao-dong Cong
    Ming Xu
    Scientific Reports, 8
12