Multiple mechanisms underlie burst firing in rat midbrain doparnine neurons in vitro

被引：51
|
作者：
Johnson, SW
Wu, YN
机构：
[1] Portland VA Med Ctr, Portland, OR 97207 USA
[2] Oregon Hlth Sci Univ, Dept Neurol, Portland, OR 97239 USA
来源：
BRAIN RESEARCH | 2004年 / 1019卷 / 1-2期
关键词：
apamin; nifedipine; N-methyl-D-aspartate; substantia nigra; ventral tegmental area;
D O I：
10.1016/j.brainres.2004.06.022
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Both apamin and NMDA evoke burst firing in dopamine neurons recorded intracellularly in slices of rat midbrain. However, apamin-induced bursting required injection of depolarizing currents, and was mimicked by Bay K8644 and blocked by nifedipine. In contrast, NMDA-induced bursting required hyperpolarizing currents and was not blocked by nifedipine. Our results show that burst firing can be evoked in dopamine neurons via two different mechanisms. (C) 2004 Elsevier B.V. All rights reserved.
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页码：293 / 296
页数：4
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