Mohs micrographic surgery versus wide local excision for head and neck melanoma-in-situ

被引:10
|
作者
Phan, Kevin [1 ,2 ]
Onggo, James [3 ]
Loya, Asad [4 ]
机构
[1] Liverpool Hosp, Dept Dermatol, Liverpool, Australia
[2] UNSW, South Western Sydney Clin Sch, Liverpool, Australia
[3] Box Hill Hosp, Melbourne, Vic, Australia
[4] Baylor Coll Med, Houston, TX 77030 USA
关键词
Mohs micrographic surgery; melanoma-in-situ; melanoma; wide local excision; head and neck; LENTIGO MALIGNA MELANOMA; SUN-EXPOSED SKIN; STAGED EXCISION; FROZEN-SECTIONS; PERMANENT SECTIONS; SURGICAL MARGINS; MELANOCYTES; EPIDEMIOLOGY; RELIABILITY; DIAGNOSIS;
D O I
10.1080/09546634.2019.1639605
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Various surgical options can be used to remove melanoma in situ (MIS). These include wide local excision (WLE), staged excision, and Mohs micrographic surgery (MMS). For MIS lesions located in the head and neck regions, the WLE approach may not always be a technically feasible option if both cosmesis and anatomical function is to be preserved. Methods: We performed a retrospective analysis of the Surveillance, Epidemiology, and End Results (SEERs) cancer registry. A total of 7933 cases of MIS in the head and neck region were included in this study, of which 5353 cases were treated by WLE and the remaining 2580 cases by MMS. Results: Comparing between the WLE and MMS group, cancer-specific survival rates at 5 (99% vs. 99%) and 10 years (98% vs. 98%) as well as the 5 year overall survival rate (85% vs. 86%) were similar. After adjusting for confounders, there was no significant difference in cancer-specific survival (HR: 0.902, 95% confidence interval (CI): 0.539-1.511, p = .695) and overall-survival (HR: 0.943, 0.813-1.093, p = .435). Conclusions: For cosmetic and functional purposes, MMS is a valid and suitable alternative to WLE to treat MIS due to its tissue-preserving nature particularly in the head and neck region.
引用
收藏
页码:559 / 562
页数:4
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