Leg ulcers in sickle cell disease

Leg ulcers are a frequent complication in patients with sickle cell anemia and S/beta thalassemia causing significant physical disability and negative psychologic and social impact. Systematic conservative approaches to treatment using gentle debridement and control of edema result in rapid healing of most ulcers. Chronic recalcitrant ulcers are a challenge to the clinician and patient. Controlled clinical trials are not available to fully define the therapeutic approach to the chronic leg ulcers.