Thiolato-bridged dinuclear arene ruthenium complexes and their potential as anticancer drugs

被引：122
|
作者：
Furrer, Julien [1 ]
Suess-Fink, Georg [2 ]
机构：
[1] Univ Bern, Dept Chem & Biochem, Freiestr 3, CH-3012 Bern, Switzerland
[2] Univ Neuchatel, Inst Chim, Ave Bellevaux 51, CH-2000 Neuchatel, Switzerland
来源：
COORDINATION CHEMISTRY REVIEWS | 2016年 / 309卷
基金：
瑞士国家科学基金会;
关键词：
Ruthenium; Dinuclear complexes; Bioorganometallic chemistry; Anticancer; Glutathione oxidation; IN-VITRO; STRUCTURAL-CHARACTERIZATION; DIRUTHENIUM COMPLEXES; DNA-BINDING; RUTHENIUM(II)-ARENE COMPLEXES; MOLECULAR-STRUCTURE; BENZENE COMPLEXES; REACTIVITY; DESIGN; CANCER;
D O I：
10.1016/j.ccr.2015.10.007
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Water-soluble arene ruthenium complexes have been intensively studied as cytotoxic compounds for the last fifteen years, notably owing to the promising in vitro and in vivo evaluations of, respectively, RAPTA-C (eta(6)-p-MeC6H4Pri)Ru(P-pta)Cl-2 (pta = 1,3,5-triaza-7-phospha-tricyclo-[3.3.1.1]decane) from Dyson's laboratory, and the (i-arene)Ru(en)Cl](+) (en = ethylenediamine, RAED) family of compounds from Sadler's laboratory. In this account we describe the discovery of thiolato-bridged dinuclear arene ruthenium complexes and highlight subsequent developments in the field, including their syntheses, structures, and the recent strategies for the design of thiolato-bridged dinuclear arene ruthenium bioconjugates. (C) 2015 Elsevier B.V. All rights reserved.
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收藏
页码：36 / 50
页数：15
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