Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state

被引：4

作者：

Aoki, Yuta ^{[1
]}

Mizoguchi, Hirokazu ^{[1
]}

Watanabe, Chizuko ^{[1
]}

Sakurada, Tsukasa ^{[2
]}

Sakurada, Shinobu ^{[1
]}

机构：

[1] Tohoku Pharmaceut Univ, Dept Physiol & Anat, Aoba Ku, Sendai, Miyagi 9818558, Japan

[2] Daiichi Coll Pharmaceut Sci, Dept Pharmacol 1, Minami Ku, Fukuoka 8158511, Japan

来源：

NEUROSCIENCE LETTERS | 2014年 / 560卷

关键词：

Inflammatory pain; Narcotic analgesic; Antinociception; mu-Receptor; Mice; PERIPHERAL INFLAMMATION; TOLERANCE; HYPERALGESIA; MODEL;

D O I：

10.1016/j.neulet.2013.12.020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Antinociceptive effect of narcotic analgesics, fentanyl, oxycodone and methadone in inflammatory pain state was described in the von Frey filament test using the complete Freund's adjuvant (CFA)-induced mouse inflammatory pain model. After the i.pl. injection of CFA, mechanical allodynia (decrease of mechanical threshold) was observed in ipsilateral paw. The antinociceptive effect of fentanyl and oxycodone injected s.c. against mechanical allodynia in inflammatory pain state was reduced bilaterally at 1 day after CFA pretreatment. However, the antinociceptive effect of methadone injected s.c. against mechanical allodynia in inflammatory pain state was reduced unilaterally at 1 day after CFA pretreatment. Moreover, the reduction of the antinociceptive effect of methadone in ipsilateral paw on inflammatory pain state was smaller than those of fentanyl or oxycodone. In conclusion, the alternation of the antinociceptive effect of narcotic analgesics in inflammatory pain state is variable among the narcotic analgesics used. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：122 / 125

页数：4

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