Synthesis and reactions of 1-benzyl-3-haloalkyl-5-chloropyrazoles

被引：4
|
作者：
Rudyakova, E. V. [1 ]
Savosik, V. A. [1 ]
Evstaf'eva, I. T. [1 ]
Kondrashov, E. V. [1 ]
Levkovskaya, G. G. [1 ]
机构：
[1] Russian Acad Sci, Siberian Div, Faworsky Irkutsk Inst Chem, Irkutsk 664033, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 45卷 / 05期
关键词：
DERIVATIVES;
D O I：
10.1134/S1070428009050108
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesized 1-benzyl-3-chloroalkyl-5-chloropyrazoles reacted with indole and pyrrole in DMSO in the presence of alkali to give 3-(heter-1-yl)alkyl-substituted 1-benzyl-5-chloropyrazoles. 1-[(1-Benzyl-5-chloropyrazol-3-yl)methyl]indole reacted regiospecifically with chloroal trifluoromethylsulfonyl- and 4-chlorophenylsulfonylimines providing the products of C-amidotrichloroethylation into the position 3 of the indole ring. {1-[(1-Benzyl-5-chloropyrazol-3-yl)methyl]indol-3-yl}sulfanylacetic acid was obtained by the reaction of 1-[(1-benzyl-5-chloropyrazol-3-yl)methyl]-indole with iodine, thiourea, and chloroacetic acid.
引用
收藏
页码：705 / 711
页数：7
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