From the laboratory to the clinic: How translational studies in animals have lead to clinical advances in boron neutron capture therapy

被引：6
|
作者：
Barth, Rolf F. [1 ]
机构：
[1] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA
来源：
APPLIED RADIATION AND ISOTOPES | 2015年 / 106卷
基金：
美国国家卫生研究院;
关键词：
Sodium borocaptate (BSH); Boronophenylalanine (BPA); Melanomas and brain tumors; Optimization of delivery of BSH and BPA; DIAGNOSED GLIOBLASTOMA-MULTIFORME; BRAIN-BARRIER DISRUPTION; PARA-BORONOPHENYLALANINE; INTRACAROTID INJECTION; P-BORONOPHENYLALANINE; SODIUM BOROCAPTATE; ENHANCED SURVIVAL; TUMORS; DELIVERY;
D O I：
10.1016/j.apradiso.2015.06.016
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In this report five examples have been selected to illustrate how studies in experimental animals have lead directly to clinical implementation. These include (1) the use of BSH as a boron delivery agent for BNCT of patients with brain tumors, and more specifically gliomas; (2) the use of BPA as a delivery agent for BNCT for patients with melanomas and (3) its subsequent use for BNCT of patients with gliomas; (4) optimization of the delivery of BPA in patients with gliomas; and finally (5) the combination of BSH and BPA with BNCT alone or together with X-irradiation to treat patients with gliomas. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：22 / 28
页数：7
相关论文
共 32 条
  • [1] The basis and advances in clinical application of boron neutron capture therapy
    Huifang He
    Jiyuan Li
    Ping Jiang
    Suqing Tian
    Hao Wang
    Ruitai Fan
    Junqi Liu
    Yuyan Yang
    Zhibo Liu
    Junjie Wang
    Radiation Oncology, 16
  • [2] The basis and advances in clinical application of boron neutron capture therapy
    He, Huifang
    Li, Jiyuan
    Jiang, Ping
    Tian, Suqing
    Wang, Hao
    Fan, Ruitai
    Liu, Junqi
    Yang, Yuyan
    Liu, Zhibo
    Wang, Junjie
    RADIATION ONCOLOGY, 2021, 16 (01)
  • [3] ADVANCES IN CLINICAL APPLICATION OF BORON NEUTRON CAPTURE THERAPY (BNCT) IN GLIOBLASTOMA
    Detta, A.
    Cruickshank, G. C.
    Green, S.
    Lockyer, N. P.
    Ngoga, D.
    Ghani, Z.
    Phoenix, B.
    NEURO-ONCOLOGY, 2014, 16
  • [4] Translational boron neutron capture therapy (BNCT) studies for the treatment of tumors in lung
    Andrea Trivillin, Veronica
    Serrano, Ayelen
    Garabalino, Marcela A.
    Luis Colombo, Lucas
    Cesar Pozzi, Emiliano
    Monti Hughes, Andrea
    Curotto, Paula M.
    Ines Thorp, Silvia
    Farias, Ruben O.
    Gonzalez, Sara J.
    Bortolussi, Silva
    Altieri, Saverio
    Itoiz, Maria E.
    Aromando, Romina F.
    Nigg, David W.
    Schwint, Amanda E.
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2019, 95 (05) : 646 - 654
  • [5] Boron neutron capture therapy - Clinical brain tumor studies
    Nakagawa, Y
    Hatanaka, H
    JOURNAL OF NEURO-ONCOLOGY, 1997, 33 (1-2) : 105 - 115
  • [6] Boron neutron capture therapy: Clinical brain tumor studies
    Yoshinobu Nakagawa
    Hiroshi Hatanaka†
    Journal of Neuro-Oncology, 1997, 33 : 105 - 115
  • [7] Neutron activation and dosimetry studies for a clinical facility of Boron Neutron Capture Therapy
    Magni, C.
    Ferrarini, M.
    Postuma, I.
    Protti, N.
    Fatemi, S.
    Gong, C.
    Anselmi-Tamburini, U.
    Vercesi, V.
    Battistoni, G.
    Bortolussi, S.
    NUOVO CIMENTO C-COLLOQUIA AND COMMUNICATIONS IN PHYSICS, 2021, 44 (4-5):
  • [8] Boron Neutron Capture Therapy for Glioblastoma Multiforme: Clinical Studies in Sweden
    Jacek Capala
    Britta H. -Stenstam
    Kurt Sköld
    Per Munck af Rosenschöld
    Valerio Giusti
    Charlotta Persson
    Eva Wallin
    Arne Brun
    Lars Franzen
    Jörgen Carlsson
    Leif Salford
    Crister Ceberg
    Bertil Persson
    Luigi Pellettieri
    Roger Henriksson
    Journal of Neuro-Oncology, 2003, 62 : 135 - 144
  • [9] Boron neutron capture therapy for glioblastoma multiforme:: clinical studies in Sweden
    Capala, J
    Stenstam, BH
    Sköld, KS
    af Rosenschöld, PM
    Giusti, V
    Persson, C
    Wallin, E
    Brun, A
    Franzen, L
    Carlsson, JO
    Salford, L
    Ceberg, C
    Persson, B
    Pellettieri, L
    Henriksson, R
    JOURNAL OF NEURO-ONCOLOGY, 2003, 62 (01) : 135 - 144
  • [10] Boron neutron capture therapy for glioblastoma multiforme: clinical studies in Sweden
    Jacek Capala
    Britta H.-Stenstam
    Kurt Sköld
    Per Munck af%Rosenschöld
    Valerio Giusti
    Charlotta Persson
    Eva Wallin
    Arne Brun
    Lars Franzen
    Jörgen Carlsson
    Leif Salford
    Crister Ceberg
    Bertil Persson
    Luigi Pellettieri
    Roger Henriksson
    Journal of Neuro-Oncology, 2003, 62 (1-2) : 135 - 144
1234