EVALUATION OF ADL5747, A NEW DELTA OPIOID RECEPTOR (DOR) AGONIST, IN HEALTHY HUMAN VOLUNTEERS

被引：0
|
作者：
Leese, Philip [1 ]
Croom, John [2 ]
Berger, Bruce [3 ]
机构：
[1] Quintiles Phase I Serv, Overland Pk, KS USA
[2] St Lukes Hosp, Comprehens Epilepsy Ctr, Kansas City, MO USA
[3] Adolor Corp, Exton, PA USA
来源：
JOURNAL OF CLINICAL PHARMACOLOGY | 2009年 / 49卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
25
引用
收藏
页码：1096 / 1096
页数：1
相关论文
共 50 条
  • [1] δ-Opioid Mechanisms for ADL5747 and ADL5859 Effects in Mice: Analgesia, Locomotion, and Receptor Internalization
    Nozaki, Chihiro
    Le Bourdonnec, Bertrand
    Reiss, David
    Windh, Rolf T.
    Little, Patrick J.
    Dolle, Roland E.
    Kieffer, Brigitte L.
    Gaveriaux-Ruff, Claire
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2012, 342 (03): : 799 - 807
  • [2] SAFETY, TOLERABILITY AND PHARMACOKINETICS OF ADL5859, A NOVEL DELTA OPIOID RECEPTOR AGONIST (DORA), IN HEALTHY HUMAN VOLUNTEERS
    Leese, P.
    Schomer, D.
    Berger, B.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2009, 85 : S41 - S41
  • [3] Delta Opioid Receptor (DOR) Agonist Activity of Buprenorphine in Mice
    Burgess, Gwendolyn
    Amin, Sajni
    Jutkiewicz, Emily
    FASEB JOURNAL, 2021, 35
  • [4] Development of bifunctional mu opioid receptor (MOR) agonist/delta opioid receptor (DOR) antagonist peptides and peptidomimetics
    Mosberg, Henry I.
    Anand, Jessica
    Bender, Aaron
    Harland, Aubrie A.
    Sobczyk-Kojiro, Katarzyna
    Yeomans, Larisa
    Jutkiewicz, Emily M.
    Traynor, John
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
  • [5] Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)
    Le Bourdonnec, Bertrand
    Windh, Rolf T.
    Leister, Lara K.
    Zhou, Q. Jean
    Ajello, Christopher W.
    Gu, Minghua
    Chu, Guo-Hua
    Tuthill, Paul A.
    Barker, William M.
    Koblish, Michael
    Wiant, Daniel D.
    Graczyk, Thomas M.
    Belanger, Serge
    Cassel, Joel A.
    Feschenko, Marina S.
    Brogdon, Bernice L.
    Smith, Steven A.
    Derelanko, Michael J.
    Kutz, Steve
    Little, Patrick J.
    DeHaven, Robert N.
    DeHaven-Hudkins, Diane L.
    Dolle, Roland E.
    JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (18) : 5685 - 5702
  • [6] Respiratory Effects of the Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist, Cebranopadol, in Healthy Human Volunteers
    Dahan, Albert
    Boom, Merel
    Sarton, Elise
    Hay, Justin
    Groeneveld, Geert Jan
    Neukirchen, Meike
    Bothmer, John
    Aarts, Leon
    Olofsen, Erik
    ANESTHESIOLOGY, 2017, 126 (04) : 697 - 707
  • [7] Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists
    Tanguturi, Parthasaradhireddy
    Pathak, Vibha
    Zhang, Sixue
    Moukha-Chafiq, Omar
    Augelli-Szafran, Corinne E.
    Streicher, John M.
    MOLECULES, 2021, 26 (21):
  • [8] Sensorimotor gating and attentional set-shifting are improved by the μ-opioid receptor agonist morphine in healthy human volunteers
    Quednow, Boris B.
    Csomor, Philipp A.
    Chmiel, Joelle
    Beck, Thilo
    Vollenweider, Franz X.
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2008, 11 (05): : 655 - 669
  • [9] PHARMACODYNAMICS OF A NEW KAPPA-OPIOID AGONIST, NIRAVOLINE, IN HEALTHY-VOLUNTEERS
    BELLISSANT, E
    DENOLLE, T
    SINNASSAMY, P
    LECOZ, F
    GANDON, JM
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1995, 57 (02) : 142 - 142
  • [10] Evaluation of a New Motilin Receptor Agonist, GSK962040, on the Migrating Motor Complex and Gastric pH in Healthy Human Volunteers
    Deloose, Eveline
    Vos, Rita
    Dewit, Odile
    Dukes, George E.
    de Hoon, Jan
    Van Hecken, Anne
    Tack, Jan F.
    GASTROENTEROLOGY, 2012, 142 (05) : S841 - S841
12345