Recent progress in satellite cell/myoblast engraftment - relevance for therapy

被引：67

作者：

Briggs, Deborah ^{[1
]}

Morgan, Jennifer E. ^{[1
]}

机构：

[1] UCL Inst Child Hlth, Dubowitz Neuromuscular Ctr, London WC1N 1EH, England

来源：

FEBS JOURNAL | 2013年 / 280卷 / 17期

基金：

英国惠康基金; 英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

cell therapy; Duchenne muscular dystrophy; mdx mouse; muscular dystrophy; myoblasts; satellite cells; skeletal muscle regeneration; DUCHENNE MUSCULAR-DYSTROPHY; MUSCLE PRECURSOR CELLS; HUMAN MYOBLAST TRANSPLANTATION; PLURIPOTENT STEM-CELLS; HEAT-SHOCK TREATMENT; SKELETAL-MUSCLE; SELF-RENEWAL; MYOGENIC CELLS; AUTOLOGOUS TRANSPLANTATION; STEM/PROGENITOR CELLS;

D O I：

10.1111/febs.12273

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is currently no cure for muscular dystrophies, although several promising strategies are in basic and clinical research. One such strategy is cell transplantation with satellite cells (or their myoblast progeny) to repair damaged muscle and provide dystrophin protein with the aim of preventing subsequent myofibre degeneration and repopulating the stem cell niche for future use. The present review aims to cover recent advances in satellite cell/myoblast therapy and to discuss the challenges that remain for it to become a realistic therapy.

引用

页码：4281 / 4293

页数：13

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